Results 41 to 50 of about 1,645 (243)

Fault-tolerant basis and fault-tolerant edge basis of three classes of French windmill graphs

Ain Shams Engineering Journal
A resolving set is a subset of vertices that uniquely identifies every vertex based on distances. A fault-tolerant resolving set maintains this condition under any single-vertex removal, and the minimum size of such a set is the fault-tolerant metric ...
S. Prabhu, P. Angelin Kiruba, A. Davoodi, Paul Manuel   +3 more
doaj   +1 more source

Fault-tolerant edge metric dimension of certain families of graphs

AIMS Mathematics, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Xiaogang Liu, Muhammad Ahsan, Zohaib Zahid, Shuili Ren   +3 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fault tolerance for metric dimension and its variants

Discrete Applied Mathematics
Hernando et al. (2008) introduced the fault-tolerant metric dimension $\text{ftdim}(G)$, which is the size of the smallest resolving set $S$ of a graph $G$ such that $S-\left\{s\right\}$ is also a resolving set of $G$ for every $s \in S$. They found an upper bound $\text{ftdim}(G) \le \dim(G) (1+2 \cdot 5^{\dim(G)-1})$, where $\dim(G)$ denotes the ...
Jesse Geneson, Shen-Fu Tsai
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Minimum Fault-Tolerant, local and strong metric dimension of graphs

Ars Comb., 2014
In this paper, we consider three similar optimization problems: the fault-tolerant metric dimension problem, the local metric dimension problem and the strong metric dimension problem. These problems have applications in many diverse areas, including network discovery and verification, robot navigation and chemistry, etc.
Muhammad Salman, Imran Javaid, Muhammad Anwar Chaudhry   +2 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Computing Basis and Dimension of Chloroquine and Hydroxychloroquine by Using Chemical Graph Theory

, 2023
Discovering a vaccine with reliable and effective treatment for the new corona virus disease 2019 (COVID-19) is indeed a long way off, and there seems to be a critical need to research additional viable medications that could save countless lives in the ...
Raza, Hassan, Hassan Raza, Yogesh Singh, Sharma, Sunny Kumar, Sunny Kumar Sharma, Singh, Yogesh, Vijay Kumar Bhat, Bhat, Vijay Kumar   +7 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source