Results 71 to 80 of about 8,774,500 (286)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A voltage-clamped bidirectional fault current limiter based on a three-winding coupled inductor for DC power grids

International Journal of Electrical Power & Energy Systems
The DC fault is a serious challenge to voltage-source-converter-based HVDC (VSC-HVDC) systems, and the fault current limiter (FCL) is one of the key measures to solve the DC fault and reduce the capacity of the DC circuit breaker.
Ziao Yuan, Siyuan Liu, Jinchao Chen, Zhiyuan Liu, Yingsan Geng   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Design and test of a magnetic saturation-type fault current limiter

The Journal of Engineering, 2019
Fault current limiter (FCL) is an effective technique for the fault isolation and protection in the direct current (DC) grid. In this study, a magnetic saturation-type FCL is designed and tested. Firstly, its basic principle is introduced.
Lu Qu, Rong Zeng, Zhanqing Yu, Ge Li
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Quenched Flux-Coupling Superconducting Fault Current Limiter Scheme and Its Electromagnetic Design Method. [PDF]

Materials (Basel), 2023
Yan S, Ren L, Zhao J, Xu Y, Shen S, Xiong Y, Liu B, Xiao F.   +7 more
europepmc   +1 more source

Parallel Resonance Fault Current Limiter for DFIG Wind Turbine Transient Stability

Jurnal Elkomika
The increasing penetration of renewable energy, especially wind energy based on Dubly Fed Induction Generator (DFIG), poses challenges in maintaining power system stability. One mitigation approach is the use of a Parallel Resonance Fault Current Limiter
RULI AMAR MA’RUF, ZULMIFTAH HUDA, HERRI GUSMEDI   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Combining finite element and reinforcement learning methods to design superconducting coils of saturated iron-core superconducting fault current limiter in the DC power system. [PDF]

PLoS One, 2023
Kim CS, Dao VQ, Park J, Jang B, Lee SJ, Park M.   +5 more
europepmc   +1 more source

Improving fault ride-through capability of DFIG based wind generators by using bridge-type superconducting fault current limiter

, 2015
This paper proposes series connection of a diode bridge-type superconducting fault current limiter (SFCL) with rotor side converter (RSC) of a double fed induction generator (DFIG) based wind turbine.
Ahmed M. A. Haidar, Hossain, M. S. A., K. M. Muttaqi, M. Tarafdar Hagh, Hagh, M. Tarafdar, Sutanto, D., D. Sutanto, Muttaqi, K. M., M. S. A. Hossain, Haidar, Ahmed M. A.   +9 more
core   +1 more source