Results 101 to 110 of about 6,022,636 (288)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

HTS Partial Core Transformer - Fault Current Limiter [PDF]

, 2013
This paper presents a HTS partial core transformer-fault current limiter that was designed and built at the University of Canterbury. The transformer was tested under no load, short circuit and full load conditions, followed by a test with a short ...
Bodger, P., Sham, J.K.
core   +1 more source

Analisa Penggunaan Superconducting Fault Current Limiter (SFCL) Untuk Melindungi Peralatan di PT Pindo Deli

Jurnal Teknik ITS, 2015
Increas demand load and power capacity requirement at PT Pindo Deli then the short circuit current that occur will be greater. this can cause damage to electrical equipment located around the point of interrupting and resulting failure of the electrical ...
Yohanes Sabriant Widyo Utomo, Margo Pujiantara, Arif Musthofa   +1 more
doaj  

Improved Low Voltage Ride-Through Capability of DFIG with ESO Controller under Unbalanced Network Conditions

Majlesi Journal of Electrical Engineering
Under unbalanced grid condition, in a Doubly-Fed Induction Generator (DFIG), voltage, current, and flux of the stator become asymmetric. Therefore, active-reactive power and torque will be oscillating.
Ali Akbar Vali, Seyed Mohammad Hassan Hosseni, Javad Olamaei   +2 more
doaj   +1 more source

Fault ride-through enhancement of fixed speed wind turbine using bridge-type fault current limiter

Journal of Electrical Systems and Information Technology, 2016
The interaction between wind energy turbines and the grid results in two main problems, increasing the short-circuit level and reducing the Fault Ride-Through (FRT) capability during faults.
Mostafa I. Marei, Hamdy S.K. El-Goharey, Randa M. Toukhy   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Optimal allocation of fault current limiters for sustaining overcurrent relays coordination in a power system with distributed generation

Alexandria Engineering Journal, 2015
This paper addresses the problem of overcurrent relays (OCRs) coordination in the presence of DGs. OCRs are optimally set to work in a coordinated manner to isolate faults with minimal impacts on customers.
A. Elmitwally, E. Gouda, S. Eladawy
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source