Results 71 to 80 of about 7,553,650 (283)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Superconducting Fault Current Limiters for HVDC Systems

Energy Procedia, 2015
AbstractHigh-voltage direct current (HVDC) transmission systems using Voltage-Source Converters (VSC) are widely recognized as offering significant potential for long distance high power delivery, particularly for offshore wind farm connections. One of the barriers for the development of multi-terminal HVDC systems is the lack of technologies which ...
Pei, Xiaoze, Smith, Alexander; id_orcid 0000-0001-6782-4627, Barnes, Michael   +2 more
openaire   +3 more sources

High-Tc Superconducting Fault Current Limiting Transformer ( HTc-SFCLT ) With 2G Coated Conductors [PDF]

, 2007
We developed a 3-phase, 100 kVA, 6600 V/210 V high temperature Superconducting Fault Current Limiting Transformer (HTc-SFCLT) with functions of both superconducting transformer and fault current limiter.
Okubo, H., Endo, F., Kurupakorn, C., Kojima, H., Ito, S., Noe, M., Hayakawa, N.   +6 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Fault Current Limitation Coordination in Electric Power Grid With Superconducting Fault Current Limiters

IEEE Transactions on Applied Superconductivity, 2018
This paper proposes the concept of “fault current limitation coordination” in a future electric power grid with multiple superconducting fault current limiters (SFCL). Not only the fault current limitation of each SFCL on a transmission line, but also the transient stability of the grid with SFCLs should be taken into account, because the disturbance ...
Naoki Hayakawa, Yuya Maeno, Hiroki Kojima   +2 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Limitation of Fault Currents by Positioning of Superconducting Fault Current Limiter in AC and DC Microgrid

International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering, 2015
Different types of distributed generation (DG) sources could be connected to the main power grid in order to improve the reliability of the power system, in a smart grid. The association of ac and dc distribution grid are assigned for the efficient connection of renewable power resources.
K. Sreedhar Kumar, J N Chandra Sekhar
openaire   +1 more source

Improvement of Protection Coordination for a Distribution System Connected to a Microgrid using Unidirectional Fault Current Limiter

Ain Shams Engineering Journal, 2017
The presence of distributed generation (DG) units in distribution systems increases the fault current level, which disrupts the existing coordination time interval of the protective overcurrent relays.
Mazen Abdel-Salam, Ahmed Abdallah, Rashad Kamel, Mohamed Hashem   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source