Results 61 to 70 of about 36,327 (304)

The state diagnosis method of metal enclosed gas insulation complete equipment based on deep learning algorithms

Mechanics & Industry
The reliable operation of metal-enclosed gas-insulated equipment is crucial to high-voltage power systems, and accurate diagnosis of its status is the key to ensuring safe and efficient operation of the power grid.
Wang Jiayi, Zhou Dianbo, Fang Yuan, Long Zhenze, He Yuhang, Luo Xinyu, Zou Yang   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Classification of multiple electromagnetic interference events in high-voltage power plant [PDF]

, 2018
This paper addresses condition assessment of electrical assets contained in high voltage power plants. Our work introduces a novel analysis approach of multiple event signals related to faults, and which are measured using Electro-Magnetic Interference ...
Boreham, Philip, Hughes-Narborough, Michael, Mitiche, Imene, Morison, Gordon, Nesbitt, Alan, Stewart, Brian G.   +5 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Open-Switch Fault Diagnosis Method in Voltage-Source Inverters Based on Phase Currents

IEEE Access, 2019
Presently, condition monitoring and fault diagnostics in the three-phase voltage-source inverter (VSI) system are already considered essential to improve maintenance efficiency and increase reliability levels.
Zhang Jian-Jian, Chen Yong, Chen Zhang-Yong, Zhou Anjian   +3 more
doaj   +1 more source

Embedded intelligence for electrical network operation and control [PDF]

, 2011
Integrating multiple types of intelligent, mulitagent data analysis within a smart grid can pave the way for flexible, extensible, and robust solutions to power network ...
Catterson, Victoria, Davidson, Euan, Mcarthur, Stephen   +2 more
core   +1 more source

Active actuator fault detection and diagnostics in HVAC systems

Proceedings of the Fourth ACM Workshop on Embedded Sensing Systems for Energy-Efficiency in Buildings, 2012
This paper introduces a new method for performing actuator fault detection and diagnostics (FDD) in heating ventilation and air conditioning (HVAC) systems. The proposed actuator FDD strategy, for testing whether an actuator is stuck in a single position, uses a two-tier approach that includes a dynamic model-based detector and a fast-deciding steady ...
Weimer, James, Ahmadi, Alireza, Araujo, José, Mele, F., Papale, D., Shames, Iman, Sandberg, Henrik, Johansson, Karl Henrik   +7 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source