Results 51 to 60 of about 2,065,188 (309)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Structural architecture and late Cenozoic tectonic evolution of the Ulsan Fault Zone, SE Korea: New insights from integration of geological and geophysical data

Frontiers in Earth Science, 2023
Integration of geological and geophysical data is essential to elucidate the configuration and geometry of surface and subsurface structures, as well as their long-term evolution.
Youngbeom Cheon, Young Hong Shin, Samgyu Park, Jin-Hyuck Choi, Dong-Eun Kim, Kyoungtae Ko, Chung-Ryul Ryoo, Young-Seog Kim, Moon Son   +8 more
doaj   +1 more source

Evaluating models of Coulomb stress transfer: Is variable fault geometry important?

, 2016
To determine the importance of receiver fault geometry in Coulomb stress calculations a new methodology is presented to model faults with variable geometry.
Z. Mildon, S. Toda, J. F. Faure Walker, G. Roberts   +3 more
semanticscholar   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Using historical aerial images to accurately locate the urban "invisible" active faults: A case study of the Shuiyu fault of the Datong Basin in Shanxi province

Dizhi lixue xuebao, 2021
Active fault is a major risk source of urban earthquake disaster. Accurately identifying the spatial geometry distribution features of active fault is the basis for urban seismic risk migration.
GUO Fei, REN Junjie, GUO Hui, SU Qiang, REN Jianguo, YAN Xiaobing   +5 more
doaj   +1 more source

Hopfield Neural Networks for Online Constrained Parameter Estimation With Time‐Varying Dynamics and Disturbances

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley   +1 more source

Fluid flow in crustal fault zones with varying lengthwise thickness: application to the Margeride fault zone (French Massif Central)

Geothermal Energy
Crustal fault zones, holding promise as potential geothermal reservoirs, remain largely untapped and unexplored. Located in the southern Massif Central, France, the Margeride fault zone (MFZ) varies in thickness (lateral extension perpendicular to the ...
Emmy Penhoët, Laurent Arbaret, Laurent Guillou-Frottier, Hugo Duwiquet, Charles Gumiaux, Mathieu Bellanger   +5 more
doaj   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Mexico Quaternary Fault Database

Terra Digitalis, 2017
  We present a Geographic Information System (GIS) database that synthesizes information on the geometry, the sense of movement and the last displacement on known Quaternary faults in Mexico.
Gonzalo Cid Villegas, Carlos Mendoza, Luca Ferrari   +2 more
doaj   +1 more source