Results 171 to 180 of about 3,205 (249)

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

open access: yesAdvanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen   +9 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

open access: yesAdvanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio   +6 more
wiley   +1 more source

Aluminum‐Substituted Yttrium Iron Garnet Films With Perpendicular Anisotropy Grown on Silicon by Sputtering

open access: yesAdvanced Electronic Materials, EarlyView.
Ultrathin Al‐substituted YIG films with perpendicular magnetic anisotropy are sputter‐grown directly on Si/SiOx using an ultrathin AlOx buffer layer. Al diffusion reduces the saturation magnetization and stabilizes PMA via magnetoelastic effects. Pt/Al:YIG bilayers exhibit strong spin Hall magnetoresistance and efficient spin–orbit torque switching ...
Matteo Fettizio   +4 more
wiley   +1 more source

Synthesis and Characterization of Highly Conductive Cobalt Phthalocyanine‐Based Metal–Organic Framework

open access: yesAdvanced Electronic Materials, EarlyView.
A two‐dimensional (2D) layered material, CoPc‐MOF, with a cobalt phthalocyanine backbone as its structural unit, was successfully synthesized. CoPc‐MOF adopts a crystal structure analogous to a Lieb lattice, which is a type of Dirac material. CoPc‐MOF exhibits exceptionally high electrical conductivity for an organic semiconductor, which likely ...
Norihiro Morishita   +8 more
wiley   +1 more source

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