Results 101 to 110 of about 846,547 (352)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
FAULT DIAGNOSIS OF PLANETARY GEAR TRANSMISSION SYSTEM BASED ON VIBRATION RELEVANT INFORMATION FUSION
Jixie qiangdu, 2015 Considering the facts that different measurement point information provide different sensitivity degree and vibration transmission make fault relate to each measuring point,the fault diagnosis model of vibration relevant information fusion were put ...
ZHAO XiaoQing +4 more
doaj
Construction of a Geological Fault Corpus and Named Entity Recognition
Applied SciencesThe rapid and effective extraction of fault entities is a fundamental process in constructing a fault knowledge graph. As a key method for recording and preserving fault data, a fault investigation report holds significant potential for extracting ...
Huainuo Wang +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringDuring strike-slip fault dislocation, multiple fault planes are commonly observed. The resulting permanent ground deformation can lead to profound structural damage to tunnels.
Henghong Yang +3 more
doaj +1 more source
Combining faulting and ductile deformation in long-term models of continental deformation
, 2023 G. A. Houseman +2 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Research of Fault Arc of Low-voltage Distribution Line Based on Mayr Model
Gong-kuang zidonghua, 2011 In view of problems of high cost and difficult operation in practice because fault arc's research need build special experimental environment to simulate series fault arc, parallel fault arc and grounding fault arc, the paper proposed a design scheme of ...
HUO Liu-hang, DONG Ai-hua
doaj
SIFaultKin v.1.0: a dataset of fault kinematic models in southern Italy (2023).
, 2023 Marco Cuffaro +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source