Results 81 to 90 of about 846,547 (352)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Rotor Coupling Fault Mechanism Modeling Based on the Deformation-Motion Vector Analysis Method [PDF]

, 2020
Hu Jun
openalex   +1 more source

Advanced Fault Tree Modeling

, 1999
JUCS - Journal of Universal Computer Science Volume Nr.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Landslide hazard assessment of the fault zone considering the fault effect: a case study of the Lixian–Luojiabu fault zone in Gansu Province (China)

Frontiers in Earth Science
The earthquake landslide hazard assessment method is mainly based on the traditional Newmark model. However, when the landslide hazard assessment is carried out along the fault zone, the calculated results are often different from the actual situation ...
Wei Feng, Wei Feng, Yaming Tang, Hongli Ma, Bo Hong, Bo Hong   +5 more
doaj   +1 more source

Distributed fault‐tolerant model predictive control for intermittent faults

IET Control Theory & Applications, 2019
Intermittent fault is a special kind of fault form, which often occurs in industry processes but has been less studied. This study focuses on the distributed fault‐tolerant model predictive control (DFTMPC) problem for an intermittent fault in actuators or sensors. A novel state observer and DFTMPC controller integral framework are presented.
Guannan Xiao, Fei Liu
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A way to synchronize models with seismic faults for earthquake forecasting: Insights from a simple stochastic model

, 2006
Numerical models are starting to be used for determining the future behaviour of seismic faults and fault networks. Their final goal would be to forecast future large earthquakes.
Aki, Amalio F. Pacheco, Baba, Bak, Ben-Zion, Boness, Bowman, Castellaro, Dahmen, Das, Das, Dowrick, Drossel, Fitzenz, Goltz, González, González, Grant, Gutenberg, Gutenberg, Gómez, Hainzl, Hainzl, Hainzl, Harris, Hashimoto, Heimpel, Helmstetter, Henley, Hickman, Houghton, Ikeda, Ishimoto, Javier B. Gómez, Kanamori, Kanamori, Kato, Keilis-Borok, Kisslinger, Kossobokov, Kuroki, Lei, López-Ruiz, Main, Mason, Michael, Miguel Vázquez-Prada, Miller, Molchan, Moreno, Newman, Okada, Olami, Palmer, Pepke, Preston, Reasenberg, Robinson, Robinson, Rubin, Rundle, Rundle, Rundle, Rundle, Rundle, Scholz, Scholz, Schorlemmer, Schwartz, Seeber, Sieh, Soloviev, Steacy, Stirling, Stirling, Tanioka, Tiampo, Tsukahara, Turcotte, Vázquez-Prada, Vázquez-Prada, Ward, Wells, Wesnousky, Wesnousky, Wyss, Yabuki, Yagi, Yamamoto, Yeats, Youngs, Zoback, Zöller, Álvaro González   +93 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source