Results 101 to 110 of about 35,036 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transient Equivalent Modelling of a Wind Farm Based on QPSO-Based Wind Turbine Fault Ride-Through Control

Energies
At present, the equivalent modeling method of wind farms mostly adopts single-machine multiplication equivalence, which has the deficiencies of large model error and difficulty in accurately reflecting the fault transient characteristics of wind farms ...
Jianan He, Shenbing Ma, Xu Zhang, Meiling Luo, Lei Li, Jian Niu, Haitao Liu, Ping Jin, Yabo Liang   +8 more
doaj   +1 more source

Nonlinear Modeling for Fault‐tolerant Control

, 2021
As already remarked, model–based and data–driven FDI strategies have been studied for over 40 years, however they still represent an open research domain when considered to be applied to dynamic processes, and many problems are waiting to be solved ...
Castaldi, Paolo, Simani, Silvio, Silvio Simani, Paolo Castaldi   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Process fault prognosis using a fuzzy-adaptive unscented Kalman predictor [PDF]

, 2011
By monitoring the future process status via information prediction, process fault prognosis is able to give an early alarm and therefore prevent faults, when the faults are still in their early stages.
Sheng Chen, Xuemin Tian, Chen, Sheng, Tian, Xuemin, Cao, Yuping, Yu Ping Cao   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analogue modeling of through-going process and development pattern of strike-slip fault zone

Petroleum Exploration and Development, 2017
Nine sets of sand-box experiments were designed according to actual geologic data to investigate the evolution pattern and development mechanism of simple shear strike-slip fault zone using the fault CT scanning technique.
Yang XIAO, Guanghui WU, Yongliang LEI, Tingting CHEN   +3 more
doaj   +1 more source

Low-temperature thermochronology and thermokinematic modeling of deformation, exhumation, and development of topography in the central Southern Alps, New Zealand

, 2009
Apatite and zircon (U-Th)/He and fission track ages were obtained from ridge transects across the central Southern Alps, New Zealand. Interpretation of local profiles is difficult because relationships between ages and topography or local faults are ...
Herman, Frederic, Cox, Simon C., Kamp, Peter J.J., Frédéric Herman, Peter J. J. Kamp, Simon C. Cox   +5 more
core   +1 more source