Results 51 to 60 of about 1,635,492 (292)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Palaeolimnology of Lake Sapanca and identification of historic earthquake signals, Northern Anatolian Fault Zone (Turkey) [PDF]

, 2009
Lake Sapanca is located on a strand of the Northern Anatolian Fault Zone (NAFZ, Turkey), where a series of strong earthquakes (Ms >6.0) have occurred over the past hundred years. Identifying prehistoric earthquakes in and around Lake Sapanca is key to a
Werner, P, Schwab, MJ, McGee, E, Nowaczyk, N, Dulski, P, Bertrand, S, Leroy, SAG   +6 more
core   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Geometry, evolution and scaling of fault relay zones in 3D using detailed observations from outcrops and 3D seismic data [PDF]

, 2011
A new surface attribute was developed during the course of the thesis, which enables fault-related deformation – specifically, the apparent dip of mapped horizons measured in a direction perpendicular to the average strike of a fault array (here termed ...
Long, Jonathan James, LONG, JONATHAN,JAMES   +1 more
core  

Analysis of Mechanical Characteristics and Instability Law of Inverse Fault under the Influence of Mining

Earth Sciences Research Journal, 2018
In order to explore the mechanical characteristics and stability of the reverse fault under the influence of mining, an inverse mechanics model has been built under work face mining conditions, according to the law of working surface pressure ...
Yuanhui Li, Rui Zhou
doaj   +1 more source

THE KONYA FAULT ZONE

Selçuk Üniversitesi Mühendislik, Bilim ve Teknoloji Dergisi, 2004
Konya fay zonu, Konya batısında kuzeydoğu-güneybatı uzanımlı, doğuya eğimli, eğim atımlınormal faylar ile temsil edilir. Fay zonu yaklaşık 65 km uzunluğa sahip olup, Hatunsaray doğusundanbaşlayarak kuzeydoğuya Doğudağ doğusuna doğru uzanır. Fay zonu 5 km genişliğinde bir takımsüreksiz, birbirlerine az çok paralel faylardan oluşmaktadır. Fay zonu içinde
Aksoy, Rahmi, Eren, Yaşar
openaire   +2 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Fluid flow in crustal fault zones with varying lengthwise thickness: application to the Margeride fault zone (French Massif Central)

Geothermal Energy
Crustal fault zones, holding promise as potential geothermal reservoirs, remain largely untapped and unexplored. Located in the southern Massif Central, France, the Margeride fault zone (MFZ) varies in thickness (lateral extension perpendicular to the ...
Emmy Penhoët, Laurent Arbaret, Laurent Guillou-Frottier, Hugo Duwiquet, Charles Gumiaux, Mathieu Bellanger   +5 more
doaj   +1 more source