Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Wavelet-Based Health Monitoring Approach for Train Door Actuation Using Motor Current Analysis. [PDF]
Sensors (Basel)Shiao Y, Gadde P, Bollepelly M.
europepmc +1 more source
Are mutants a valid substitute for real faults in software testing?
SIGSOFT FSE, 2014 René Just +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
An On-Board Shock Absorber Detection Method for General Aviation Aircraft Landing Gears. [PDF]
Sensors (Basel)Li C, Li H, Shen Z.
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
IMPACT OF THE SUBSURFACE STRUCTURES ON THE GROUNDWATER OCCURRENCE IN THE SOUTHEASTERN PART OF WADI EL-FARIGH, WEST NILE DELTA, EGYPT. [PDF]
Egyptian Journal of Desert Research, 2000 Ahmed M.A.H. Youssef
doaj +1 more source
Hybrid quantum-classical neural networks for real-time fault detection in power systems. [PDF]
PLoS OneHashmi H +7 more
europepmc +1 more source
A Novel Directional Element for AC Lines in Systems with Inverter-Based Resources. [PDF]
Sensors (Basel)Qian K, Wen M, Xue X, Sun Z.
europepmc +1 more source
Modeling of HVAC operational faults in building performance simulation
, 2017 Rongpeng Zhang, Tianzhen Hong
semanticscholar +1 more source