Results 231 to 240 of about 891,536 (298)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Cascade of flight interception traps for large scale exploration of the otherwise unreachable canopy insect fauna. [PDF]

Sci Rep
Rafael JA, Limeira-de-Oliveira F, Oliveira IB, Lima SP, Tôrres A, Fernandes DRR, Amorim DS.   +6 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Parasitic Fauna of Free-Living <i>Chelonoidis denticulatus</i> From the Rio Acre Ecological Station and the Municipality of Cruzeiro do Sul, Western Amazon, Brazil. [PDF]

Vet Med Int
da Costa EN, Gomes CB, Madeira RG, Moura JJS, de Assis MF, Gomes APC, Silva VLB, Moraes IS, de Moraes RS, Pacheco RC, Ramos DGS, Santos FGA.   +11 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Unveiling in situ oxygen, carbon and nutrient cycling of a sponge-driven biological hotspot in the arctic. [PDF]

Sci Rep
Hanz U, Mueller B, Bart MC, Busch K, Reichart GJ, Rapp HT, de Goeij JM, Mienis F.   +7 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

First record of Sigmodon minor (Rodentia) in the early Blancan of central Mexico: Asymmetrical dispersal from the Great Plains and paleoecology inferences. [PDF]

PLoS One
Pacheco-Castro A, Carranza-Castañeda O, Wang X.   +2 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

[Acute Flacid Paralysis and Encephalitis: A Deadly Combination. Report of the Latest Case of Human Rabies in Colombia: A Reminder of a Preventable Enemy]. [PDF]

Rev Neurol
García Jimenez FA, Valencia-Rey PA, Tutalchá Oviedo K, Mejía López S, Arango Viana JC, Cuartas Ramírez JD.   +5 more
europepmc   +1 more source