Results 231 to 240 of about 251,145 (305)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Author Correction: Healthy forests safeguard traditional wild meat food systems in Amazonia. [PDF]

Nature
Antunes AP, de Araujo Lima Constantino P, Fa JE, Fa JE, Munari DP, Morcatty TQ, Jacob MCM, Nelson BW, Cassino MF, Carvalho EAR, Ickowitz A, Coad L, Bodmer RE, Mayor P, Richard-Hansen C, Valsecchi J, Campos-Silva JV, Pezzuti JCB, Aparício M, von Muhlen EM, Oliveira MA, de Paula MJ, Pimenta NC, de Mattos Vieira MAR, Santos Junior MA, Nunes AV, Boubli JP, Suruí LMG, Paumari ECS, Paumari AVC, Paumari JLVS, Paumari GC, Katukina APLR, Baniwa D, Baniwa VSM, Baniwa WSL, Baniwa AOF, Baniwa AB, Baniwa IJS, Waura Y, Silvestre Apurinã J, Apurinã VSS, Tikuna JOG, Tikuna EPAL, Kaxinauá JL, Kuikuro KB, Penaforth Kaixana JT, Rebelo GH, Torquato D, Apurinã VSF, Antúnez M, Perez-Peña PE, Fang TG, Puertas PE, Aquino RM, Maranhão L, Longin G, Lopes CKM, El Bizri HR.   +58 more
europepmc   +1 more source

RETRACTION: Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma

Molecular Oncology, EarlyView.
RETRACTION: S. Gopinath, K. Alapati, R. R. Malla, C. S. Gondi, S. Mohanam, D. H. Dinh, and J. S. Rao, “Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and Upar in Glioma,” Molecular Oncology 5, no. 5 (2011): 426–437, https://doi.org/10.1016/j.molonc.2011.07.004.
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Central Asian radiation of modern large-mammal faunas in Miocene. [PDF]

Sci Adv
Wang SQ, Jiangzuo Q, Bibi F, Zhang C, Li C, Li S, Fu J, Xing L, Jiang H, Guo D, Zhang Y, Ni X, Meng J, Deng T.   +13 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A multiverse of trophic networks and coevolutionary trajectories among holoparasitic Orobanchaceae and their animal associates: a global perspective. [PDF]

PhytoKeys
Piwowarczyk R, Wiśniewska K, Rewicz T, Olbrycht T, Salata S, Fateryga AV, Nicewicz Ł, Depa Ł, Zając K, Masarovič R, Celary W, Mielczarek Ł, Mátis A.   +12 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Assessing the Sylvatic Yellow Fever Vectors in Southern Brazil. [PDF]

Insects
Cardoso SF, Kikuti LAO, Yoshikawa AAG, Pinheiro IC, Guesser JVC, Neves MSAS, Couto-Lima D, Gatti RR, Prophiro JS, Pitaluga AN, Rona LDP.   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source