Results 71 to 80 of about 2,880,511 (277)

Prevalence and Outcome of Operative Vaginal Delivery among Mothers Who Gave Birth at Jimma University Medical Center, Southwest Ethiopia

Journal of Pregnancy, 2018
Background. Operative vaginal deliveries (OVD) are vaginal deliveries accomplished with the use of a vacuum device or forceps. If it is technically feasible and can be safely accomplished, termination of second stage labor by operative vaginal delivery ...
Zenebe Hubena, Ahadu Workneh, Yibeltal Siraneh   +2 more
doaj   +1 more source

Prenatal diagnosis of fetal digestive system malformations and pregnancy outcomes at a tertiary referral center in Fujian, China: A retrospective study

Heliyon, 2023
Fetal digestive system malformations (DSMs) are correlated with chromosomal anomalies. The prenatal diagnosis of DSMs allows for timely treatment and reduces perinatal morbidity and mortality. However, genetic screening for fetal DSMs is rarely reported.
Bin Liang, Fang Yang, Hailong Huang, Zhaozhen Liu, Qingqiang Ji, Yan Wang, Xiaoqing Wu, Yuan Lin, Lanting Xie, Wantong Zhao, Hua Cao, Liangpu Xu, Na Lin   +12 more
doaj   +1 more source

Predictors of poor perinatal outcome following maternal perception of reduced fetal movements - a prospective cohort study [PDF]

, 2012
Background: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). RFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient ...
Alexander E P Heazell, Philip J Dutton, Byrd, Louise M., Dutton, P.J., Colin P Sibley, Byrd Louise M., Kroll, J., Louise M. Byrd (152178), Lynne K. Warrander (152169), Rebecca L Jones, Kroll Josh, Dutton Philip J., Josh Kroll, Bernatavicius, G., Warrander, L.K., Jones Rebecca L., Rebecca L. Jones (152189), Dutton, Philip J., Sibley Colin P., Roberts Stephen A., Stephen A Roberts, Roberts, S.A., J. Frederik Frøen (152198), Philip J. Dutton (152166), David Gaze, Warrander, Lynne K., Lynne K Warrander, Bernatavicius, Giovanna, Kroll, Josh, Sibley, Colin P.; id_orcid, Sibley, C.P., Heazell Alexander E. P., Gaze, David, Jones, R.L., Frøen J. Frederik, Roberts, Stephen A., Alexander E. P. Heazell (152204), Heazell, A.E.P., Frøen, J. Frederik, Gaze David, Louise M Byrd, Gaze, D.C., Josh Kroll (152184), Bernatavicius Giovanna, Giovanna Bernatavicius (152175), Heazell, Alexander E P, Giovanna Bernatavicius, J Frederik Frøen, Freen, J. F., Jones, Rebecca L., Byrd, L.M., Colin P. Sibley (152195), Stephen A. Roberts (152172), Warrander Lynne K., David Gaze (152181)   +54 more
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Noninvasive prenatal diagnosis of fetal RhD status using cell-free fetal DNA in maternal plasma with TaqMan® real-time PCR assay [PDF]

, 2007
Prenatal diagnosis is now part of established obstetric practice in many countries. However, conventional methods of prenatal diagnosis of obtaining fetal tissues for genetic analysis, including amniocentesis and chorionic villus sampling, are invasive
Rekhviashvili, Tea
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome

Nature Genetics, 2023
Somatic evolutionary analysis of neuroblastoma, a pediatric tumor, proposes a common fetal time of origin. Notably, high-risk tumors exhibit early genomic instability and prolonged evolution, and this evolutionary duration predicts clinical outcomes ...
V. Körber, S. Stainczyk, R. Kurilov, K. Henrich, B. Hero, B. Brors, F. Westermann, T. Höfer   +7 more
semanticscholar   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source