Results 91 to 100 of about 9,464 (307)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

ÖRGÜTLERDE İNFORMAL İLİŞKİLERİN SOSYAL KAYTARMAYA ETKİSİNDE KAYIRMACILIĞIN ARACILIK ROLÜ

open access: yesEkonomi Maliye İşletme Dergisi
İnformal ilişkiler sınırları belirli olmayan, herhangi bir şekilde ortaya çıkabilen, farklı sebeplere dayandırılan durumlar olarak karşımıza çıkmaktadır.
Ethem Merdan, Mustafa Altıntaş
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Fear and Favoritism in the Time of COVID-19

open access: green, 2021
Baran Han   +3 more
openalex   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen   +6 more
wiley   +1 more source

Patriotic bias in sports judging – A matter of juror and athlete socialization at the national level

open access: yesCogent Social Sciences
This study examines the causes of patriotic bias in sports judging, where jurors favor athletes from their own country. It uses Olympic scoring data from figure skating and snowboarding, which represent sports with distinct socialization contexts.
Patrick Alexander Braeunig
doaj   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin   +12 more
wiley   +1 more source

Intimidade, transgressão e privança na dinâmica dos «afetos» do Antigo Regime : o caso de António Conti, o príncipe dos favoritos de D. Afonso VI (1656-1662) [PDF]

open access: yesHistória - Revista da Faculdade de Letras da Universidade do Porto, 2012
Around Antonio Maria Conti Vintimiglia – a strange and obscure Italian merchant who achieved to win the friendship and love of Afonso the 6th – the speculations are many, particularly, on the nature of the relation he has maintained with the king, along ...
Ricardo Fernando Pinto
doaj  

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