Results 151 to 160 of about 793 (190)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states. [PDF]

Neuroimage Clin
Roy N, Singleton SP, Jamison K, Mukherjee P, Shah SA, Kuceyeski A.   +5 more
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Shunt Dysfunction Assessment in Shunted Patients via Multiparametric Non-Invasive ICP Waveform Monitoring. [PDF]

Biomedicines
Bertani R, Semione G, Capitanio MZ, Brasil S, Batista S, Mendes GADS, Perret C, Ferreira C, Paiva WS, Pinto FCG.   +9 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Tracing pesticides through terrestrial food webs with wildlife at risk. [PDF]

iScience
Chen S, Li Z.
europepmc   +1 more source

High-intensity exercise training alters gut microbiota to mitigate the development of experimental autoimmune encephalomyelitis. [PDF]

Sci Rep
Hamdi L, Agranyoni O, Goldberg Y, Zarka N, Fainstein N, Theotokis P, Salamotas I, Grigoriadis N, Katz A, Ben-Hur T, Navon-Venezia S, Einstein O.   +11 more
europepmc   +1 more source

Exploring the Potential of Matching-to-Sample-Based Training Protocols to Enhance Language Abilities in Individuals with Language Impairments: A Scoping Review. [PDF]

Int J Lang Commun Disord
Maes JHR, Scheper AR, Hermans D, Vissers CTWM.   +3 more
europepmc   +1 more source

RAG suppresses group 2 innate lymphoid cells. [PDF]

Elife
Ver Heul AM, Mack M, Zamidar L, Tamari M, Yang TL, Trier AM, Kim DH, Janzen-Meza H, Van Dyken SJ, Hsieh CS, Karo JM, Sun JC, Kim BS.   +12 more
europepmc   +1 more source

Epidemiology of Non-Contact Muscle Injuries in the Italian Male Elite Under-19 Football (Soccer) Championship. [PDF]

Sports Med Open
Magistrali M, Stefanini L, Abate M, Biancalana G, Stegagno A, Cugia P, Candoli P, Anania G, Lucchese PL, Gaddi D, Volpi P, Mariani F, Boldrini L, Filippi N, Cerrone A, Sirtori C, Battaglino P, Bravin G, Del Fabro E, Berti M, Vecchini E, Minetto MA.   +21 more
europepmc   +1 more source