Results 51 to 60 of about 305,461 (343)

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

eLife, 2021
Human cytomegalovirus (HCMV) is endowed with multiple highly sophisticated immune evasion strategies. This includes the evasion from antibody mediated immune control by counteracting host Fc-gamma receptor (FcγR) mediated immune control mechanisms such ...
Philipp Kolb, Katja Hoffmann, Annika Sievert, Henrike Reinhard, Eva Merce-Maldonado, Vu Thuy Khanh Le-Trilling, Anne Halenius, Dominique Gütle, Hartmut Hengel   +8 more
doaj   +1 more source

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs. [PDF]

, 2012
The detergents used to solubilize GPCRs can make crystal growth the rate-limiting step in determining their structure. The Kobilka laboratory showed that insertion of T4-lysozyme (T4L) in the 3rd intracellular loop is a promising strategy towards ...
Baaske, Baud, Brian L. Cook, Cherezov, Chien, Christoph J. Wienken, Cook, Cook, Corin, Corin, Dahoun, Dieter Braun, Duhr, Garavito, Gimelbrant, Gimelbrant, Greenfield, Hanson, Horst Pick, Horst Vogel, Jaakola, Jacquier, Jayadev, Karolina Corin, Katada, Loll, Lu, Lu, McClintock, Philipp Baaske, Pick, Rasmussen, Ren, Rodriguez, Shimamura, Shirokova, Shuguang Zhang, Spehr, Spehr, Stefan Duhr, Wallin, Warne, Wienken, Wu   +43 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Regulation of murine hypersensitive responses by Fc receptors

Allergology International, 1998
Humoral and cellular immune responses communicate with each other via Fc receptors (FcR) expressed on various hematopoietic cells. Recent studies on several FcR knockout mice demonstrated pivotal roles of an IgG/FcγR system in the regulation of immune ...
Toshiyuki Takai, Masao Ono, Azusa Ujike, Takae Yuasa   +3 more
doaj   +1 more source

Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G. [PDF]

, 1984
We have determined that the interaction of IgG-coated erythrocytes (EIgG) and complement-coated erythrocytes (EIgMC) with macrophage Fc and complement receptors, respectively, modulates the secretion of the neutral proteinases, elastase, and plasminogen ...
Takemura, R, Werb, Z
core  

NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning [PDF]

, 2013
Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association ...
Gilmartin, Marieke R., Helmstetter, Fred J., Kwapis, Janine L.   +2 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

OncoImmunology, 2019
The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key.
Yaron Carmi, Tyler Prestwood, Edgar G. Engleman   +2 more
doaj   +1 more source

Dopamine D 4 Receptor-Deficient Mice Display Cortical Hyperexcitability [PDF]

, 2001
The dopamine D(4) receptor (D(4)R) is predominantly expressed in the frontal cortex (FC), a brain region that receives dense input from midbrain dopamine (DA) neurons and is associated with cognitive and emotional processes.
Ariano, Marjorie A., Bunzow, James R., Cepeda, Carlos, Falzone, Tomas Luis, Flores Hernandez, Jorge, Grandy, David K., Hurst, Raymond S., Kozell, Laura B., Levine, Michael S., Low, Malcolm J., Meshul, Charles K., Rubinstein, Marcelo   +11 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source