Results 1 to 10 of about 812,479 (333)

IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells

npj Vaccines, 2023
The inability of neonates to develop CD4+FoxP3-CXCR5hiPD-1hi T follicular helper (TFH) cells contributes to their weak vaccine responses. In previous studies, we measured diminished IgG responses when IL-6 was co-injected with a pneumococcal conjugate ...
Swetha Parvathaneni, Jiyeon Yang, Leda Lotspeich-Cole, Jiro Sakai, Robert C. Lee, Mustafa Akkoyunlu   +5 more
doaj   +1 more source

Genomic characterization of Bacillus cereus sensu stricto 3A ES isolated from eye shadow cosmetic products

BMC Microbiology, 2022
Background The Bacillus cereus group, also known as B. cereus sensu lato (s.l.) contains ubiquitous spore-forming bacteria found in the environment including strains from the B. cereus sensu stricto (s.s.) species. They occur naturally in a wide range of
Nadine Yossa, Rebecca Bell, Sandra Tallent, Eric Brown, Rachel Binet, Thomas Hammack   +5 more
doaj   +1 more source

qPCR detection of viable Bacillus cereus group cells in cosmetic products

Scientific Reports, 2023
Reference methods for microbiological safety assessments of cosmetics rely on culture methods that reveal colonies of live microorganisms on growth media. Rapid molecular technologies, such as qPCR, detects the presence of target DNA in samples from dead
Nadine Yossa, Sonny Huang, Travis Canida, Rachel Binet, Dumitru Macarisin, Rebecca Bell, Sandra Tallent, Eric Brown, Thomas Hammack   +8 more
doaj   +1 more source

Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet

Epigenetics, 2022
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease, and patient susceptibility to its onset and progression is influenced by several factors.
Volodymyr P. Tryndyak, Rose A. Willett, Mark I. Avigan, Arun J. Sanyal, Frederick A. Beland, Ivan Rusyn, Igor P. Pogribny   +6 more
doaj   +1 more source

Taking Biologics for Granted? Takings, Trade Secrets, and Off-Patent Biological Products [PDF]

, 2005
Biologics are complex medicines which are often genetically engineered, and which are sure to play an important role in curing some of humankind\u27s worst diseases. Not surprisingly, generic companies want a part of the biologic market. The FDA believes
Bergman, Karl-Olof, Milberg, Per, Wikstroem, Linnea   +2 more
core   +3 more sources

Novel reference genes in colorectal cancer identify a distinct subset of high stage tumors and their associated histologically normal colonic tissues

BMC Medical Genetics, 2019
Background Reference genes are often interchangeably called housekeeping genes due to 1) the essential cellular functions their proteins provide and 2) their constitutive expression across a range of normal and pathophysiological conditions.
Lai Xu, Helen Luo, Rong Wang, Wells W. Wu, Je-Nie Phue, Rong-Fong Shen, Hartmut Juhl, Leihong Wu, Wei-lun Alterovitz, Vahan Simonyan, Lorraine Pelosof, Amy S. Rosenberg   +11 more
doaj   +1 more source

Interventions and compliance

Journal of Agriculture, Food Systems, and Community Development, 2020
Preventing the spread of infectious disease relies heavily upon the development and implementation of public health interventions. The requisite debate over the effectiveness of these interventions is accom­panied by discussions about which, if any ...
Girvin Liggans, Devin Dutilly, Komita Carrington-Liggans, Mary Cartagena, Charles Idjagboro, Laurie Williams, Glenda Lewis, Mia Russell, Veronica Moore, Robert Sudler   +9 more
doaj   +1 more source

COVID-19 – Therapeutic controversies. The case of ibuprofen [PDF]

Romanian Journal of Pharmaceutical Practice, 2020
Shortly after the declaration of the SARS-CoV-2 infection pandemic by the World Health Organization (WHO), a controversy erupted over the worsening of the disease by NSAIDs, particularly ibuprofen.
Camil-Eugen Vari, Alexandra Grosan, George Jitca, Bianca-Eugenia Ősz   +3 more
doaj   +1 more source

Systems validation: application to statistical programs [PDF]

, 2005
BACKGROUND: In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based approach to determining which ...
D Moher, FDA, FDA, Rickey E Carter, T Stokes, T Stokes   +5 more
core   +3 more sources

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen, Meng‐Meng Ji, Peng‐Peng Xu, Wei‐Li Zhao   +3 more
wiley   +1 more source