Results 91 to 100 of about 812,951 (357)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection
Frontiers in Microbiology, 2015 There are currently no FDA-approved therapeutics available to treat Rift Valley fever virus (RVFV) infection. In an effort to repurpose drugs for RVFV treatment, a library of FDA-approved drugs was screened to determine their ability to inhibit RVFV ...
Ashwini eBenedict +8 more
doaj +1 more source
Fermionic extensions of the Standard Model in light of the Higgs couplings [PDF]
, 2015 As the Higgs boson properties settle, the constraints on the Standard Model extensions tighten. We consider all possible new fermions that can couple to the Higgs, inspecting sets of up to four chiral multiplets.
Bizot, Nicolas, Frigerio, Michele
core +2 more sources
Tainted food—Do managers really go to jail?
Cogent Business & Management, 2018 The Centers for Disease Control and Prevention (CDC) estimates that, in the United States, “each year 48 million people get sick from a foodborne illness, 128,000 are hospitalized and 3,000 die”. In recent years, causes of such illnesses have been traced
Rickey E. Richardson +2 more
doaj +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
npj Digital MedicineTranslational research in toxicology has significantly benefited from transcriptomic profiling, particularly in drug safety. However, its application has predominantly focused on limited organs, notably the liver, due to resource constraints.
Ting Li, Xi Chen, Weida Tong
doaj +1 more source
Lost in Translation: The Gap in Scientific Advancements and Clinical Application
Frontiers in Bioengineering and Biotechnology, 2016 The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside.
Joseph eFernandez-Moure +1 more
doaj +1 more source
Level of evidence used in recommendations by the National Comprehensive Cancer Network (NCCN) guidelines beyond Food and Drug Administration approvals. [PDF]
, 2019 BackgroundA previous analysis of 113 National Comprehensive Cancer Network® (NCCN®) recommendations reported that NCCN frequently recommends beyond Food and Drug Administration (FDA)-approved indications (44 off-label recommendations) and claimed that ...
Benson, AB +8 more
core
Scientific Rationale for Waiving Clinical Efficacy Testing of Biosimilars
Drug Design, Development and Therapy, 2022 Sarfaraz Niazi Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL, USACorrespondence: Sarfaraz Niazi, Email niazi@niazi.comAbstract: After 18 years and the administration of billions of doses, there is little ...
Niazi S
doaj
Got Controversy - Milk Does [PDF]
, 2008 This article analyzes ongoing controversy over how to best label rBST-free milk. Recombinant bovine somatotropin is a genetically engineered drug administered by some farmers to their dairy herds to increase milk production. FDA first approved its use in
McCabe, Margaret Sova
core +1 more source