Results 181 to 190 of about 1,036,661 (382)
Advanced Healthcare Materials, EarlyView.Imiquimod‐loaded nanoparticles (PFSUV‐IMQ) are found to decrease liver metastasis and liver tumor burden when administered intravenously. Flow cytometry, RNA‐seq and various experiments show that the anti‐tumor response is immune‐mediated by activating dendritic cells resulting in increased CD8 T cell infiltration and activity.
Vanessa Chan +13 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez +14 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.In this study, lipid nanoparticles are tracked in vivo using DNA barcodes to determine how varying drug loadings affect their delivery behaviors in mice. A cost‐effective strategy is developed for simultaneously monitoring the biodistribution of a library of lipid nanoparticles (LNPs).
Letao Xu +5 more
wiley +1 more source
Use of cell proliferation data in cancer risk assessment: FDA view.
, 1993 Robert J. Scheuplein
openalex +1 more source
Site survey, FDA editorial note hazards of prescription drug availability on Internet [PDF]
, 1999 Nancy Tarleton Landis
openalex +1 more source
Regulating Access to Developmental Drugs for Terminally Ill Patients: Abigail Alliance v FDA [PDF]
This amicus brief was filed in support of the Abigail Alliance for Better Access to Developmental Drugs in their lawsuit to force the Food and Drug Administration to provide patient access to drugs for cancer and other life-threatening illnesses after ...
Calfee, John E. +4 more
core +1 more source