Results 21 to 30 of about 594,141 (367)
Nature Communications, 2021 SARS-CoV2 infection has been linked to a wide range of clinical severities and the immunopathology is still under intense scrutiny. Here, the authors uncover an association of antibody affinity maturation and plasma IgA levels with clinical outcome in ...
Juanjie Tang +8 more
doaj +1 more source
Molecules, 2022 This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound).
Davide Benedetto Tiz +5 more
semanticscholar +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Evaluation of Methods for Transient Transfection of a Murine Macrophage Cell Line, RAW 264.7
BioTechniques, 1999 Monocyte/macrophage cell lines are fastidious cells commonly used in transient transfection experiments. In the course of a study of gene regulation by lipopolysaccharide (LPS), we have compared several methods for DNA-mediated cell transfection to ...
C.D. Thompson +4 more
doaj +1 more source
FDA Approval Summary: Sotorasib for KRAS G12C Mutated Metastatic NSCLC.
Clinical Cancer Research, 2021 On May 28, 2021, the U.S. Food and Drug Administration (FDA) granted accelerated approval to sotorasib (Lumakras, Amgen) for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with a Kirsten rat sarcoma proto-oncogene (KRAS) G12C ...
Erica C Nakajima +15 more
semanticscholar +1 more source
Frontiers in Neurology, 2014 Neural progenitor cell expansion is critical for normal brain development and an appropriate response to injury. During the brain growth spurt, exposures to general anesthetics which either block the N-methyl D-aspartate receptor or enhance the γ ...
Shuliang eLiu +9 more
doaj +1 more source
npj Digital Medicine, 2020 At the beginning of the artificial intelligence (AI)/machine learning (ML) era, the expectations are high, and experts foresee that AI/ML shows potential for diagnosing, managing and treating a wide variety of medical conditions.
S. Benjamens +2 more
semanticscholar +1 more source
Authentication test of seasoning food materials made from turmeric using real-time PCR
Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2023 The authentication test for spices made from turmeric using real-time. This study aimed to determine whether the spice ingredients claimed to be made from turmeric actually contain turmeric, as asserted by the product.
Alfi Sophian, Ratna Purwaningsih
doaj +1 more source
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Nature Immunology, 2020 Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD).
J. Hu +17 more
semanticscholar +1 more source
An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy
Molecules, 2021 The large number of emerging antibody-drug conjugates (ADCs) for cancer therapy has resulted in a significant market ‘boom’, garnering worldwide attention.
Juliana T W Tong +3 more
semanticscholar +1 more source