Results 21 to 30 of about 1,036,661 (382)

Current FDA-Approved Therapies for High-Grade Malignant Gliomas

open access: yesBiomedicines, 2021
The standard of care (SOC) for high-grade gliomas (HGG) is maximally safe surgical resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 weeks, then adjuvant TMZ for 6 months. Before this SOC was established, glioblastoma (
Jacob P. Fisher, D. C. Adamson
semanticscholar   +1 more source

Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients

open access: yesNature Communications, 2021
SARS-CoV2 infection has been linked to a wide range of clinical severities and the immunopathology is still under intense scrutiny. Here, the authors uncover an association of antibody affinity maturation and plasma IgA levels with clinical outcome in ...
Juanjie Tang   +8 more
doaj   +1 more source

Evaluation of Methods for Transient Transfection of a Murine Macrophage Cell Line, RAW 264.7

open access: yesBioTechniques, 1999
Monocyte/macrophage cell lines are fastidious cells commonly used in transient transfection experiments. In the course of a study of gene regulation by lipopolysaccharide (LPS), we have compared several methods for DNA-mediated cell transfection to ...
C.D. Thompson   +4 more
doaj   +1 more source

Positron Emission Tomography with [18F]FLT Revealed Sevoflurane-induced Inhibition of Neural Progenitor Cell Expansion in vivo

open access: yesFrontiers in Neurology, 2014
Neural progenitor cell expansion is critical for normal brain development and an appropriate response to injury. During the brain growth spurt, exposures to general anesthetics which either block the N-methyl D-aspartate receptor or enhance the γ ...
Shuliang eLiu   +9 more
doaj   +1 more source

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

open access: yesMolecules, 2022
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound).
Davide Benedetto Tiz   +5 more
semanticscholar   +1 more source

Authentication test of seasoning food materials made from turmeric using real-time PCR

open access: yesHo Chi Minh City Open University Journal of Science - Engineering and Technology, 2023
The authentication test for spices made from turmeric using real-time. This study aimed to determine whether the spice ingredients claimed to be made from turmeric actually contain turmeric, as asserted by the product.
Alfi Sophian, Ratna Purwaningsih
doaj   +1 more source

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

open access: yes, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D   +6 more
core   +2 more sources

The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database

open access: yesnpj Digital Medicine, 2020
At the beginning of the artificial intelligence (AI)/machine learning (ML) era, the expectations are high, and experts foresee that AI/ML shows potential for diagnosing, managing and treating a wide variety of medical conditions.
S. Benjamens   +2 more
semanticscholar   +1 more source

FDA Approval Summary: Sotorasib for KRAS G12C Mutated Metastatic NSCLC.

open access: yesClinical Cancer Research, 2021
On May 28, 2021, the U.S. Food and Drug Administration (FDA) granted accelerated approval to sotorasib (Lumakras, Amgen) for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with a Kirsten rat sarcoma proto-oncogene (KRAS) G12C ...
Erica C Nakajima   +15 more
semanticscholar   +1 more source

Transplanting islet cells can fix brittle diabetes. Why isn’t it available in the U.S.? [PDF]

open access: yesCellR4, 2019
Type 1 diabetes, which affects 1.25 million American children and adults, and more than 20 million people around the world, is a challenging chronic disease caused by the body’s inability to make insulin.
C. Ricordi, A. Japour
doaj   +1 more source

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