Results 91 to 100 of about 1,900,338 (310)

Learning to fear a second-order stimulus following vicarious learning [PDF]

, 2015
Vicarious fear learning refers to the acquisition of fear via observation of the fearful responses of others. The present study aims to extend current knowledge by exploring whether second-order vicarious fear learning can be demonstrated in children ...
Andy P. Field, Chris Askew, Cohen J., Davey G. C. L., Gemma Reynolds, Mineka S., R Core Team, Rescorla R. A.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Empirical Analysis of the Role of Amplifiers, Downtoners, and Negations in Emotion Classification in Microblogs

, 2018
The effect of amplifiers, downtoners, and negations has been studied in general and particularly in the context of sentiment analysis. However, there is only limited work which aims at transferring the results and methods to discrete classes of emotions,
Klinger, Roman, Strohm, Florian
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Fear expression is suppressed by tyrosine administration [PDF]

, 2019
Animal studies have demonstrated that catecholamines regulate several aspects of fear conditioning. In humans, however, pharmacological manipulations of the catecholaminergic system have been scarce, and their primary focus has been to interfering with ...
A Gerlicher, AD Abraham, BJ Jongkees, BS Glaeser, CA Hardman, CC Luck, CJ Merz, D Hermans, D Sevenster, DE Bush, DOL Teik, F Brischoux, FA Guarraci, FA Guarraci, FC Heath, GP McNally, HD Foster, HM Lachman, J Haaker, J Haaker, J Haaker, J Morriss, JD Fernstrom, JJ Li, JM Otis, JP Johansen, K Nader, K Raczka, KA de Souza Caetano, L Colzato, L Díaz-Mataix, LM Riby, LS Colzato, LY Atlas, M Kindt, M Matsumoto, M Nasehi, M Soeter, M Toth, MC Mithoefer, MC Mithoefer, MF Davies, N Whittle, O Dennison, O Holtzman-Assif, OA Onur, P Duits, P Waelti, R Cacciaglia, R Cools, R Marzagalli, RA Rescorla, RM Visser, RS Sutton, S Lissek, S Mathôt, S-Y Tam, SA Carmack, ST Mueller, T Agren, TB Lonsdorf, TB Lonsdorf, TD Zbozinek, TF Giustino, W Schultz, Y Ho, Z Brodnik   +66 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dynamic Analysis of an Amensalism Model Driven by Multiple Factors: The Interwoven Impacts of Refuge, the Fear Effect, and the Allee Effect

Axioms
This paper investigates a model of amensalism, in which the first species is influenced by the combined effects of refuge and fear, while the second species exhibits an additive Allee effect.
Yuting Huang, Fengde Chen, Lijuan Chen, Zhong Li   +3 more
doaj   +1 more source

Long-Term Forecast of HIV/AIDS Epidemic in China with Fear Effect and 90-90-90 Strategies. [PDF]

Bull Math Biol, 2022
Xue L, Zhang K, Wang H.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Highly challenging balance program reduces fall rate in Parkinson disease [PDF]

, 2016
Published in final edited form as: J Neurol Phys Ther. 2016 January ; 40(1): 24–30. doi:10.1097/NPT.0000000000000111BACKGROUND AND PURPOSE: There is a paucity of effective treatment options to reduce falls in Parkinson disease (PD).
DeAngelis, Tamara R., Ellis, Terry, Hendron, Kathryn, Saint-Hilaire, Marie, Sparrow, David, Thomas, Cathi A.   +5 more
core   +1 more source