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Neuroimaging of Fear Extinction
2023Extinguishing fear and defensive responses to environmental threats when they are no longer warranted is a critical learning ability that can promote healthy self-regulation and, ultimately, reduce susceptibility to or maintenance of affective-, trauma-, stressor-,and anxiety-related disorders.
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The learning of fear extinction
Neuroscience & Biobehavioral Reviews, 2014Recent work on the extinction of fear-motivated learning places emphasis on its putative circuitry and on its modulation. Extinction is the learned inhibition of retrieval of previously acquired responses. Fear extinction is used as a major component of exposure therapy in the treatment of fear memories such as those of the posttraumatic stress ...
Cristiane, Furini +2 more
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Neuronal circuits of fear extinction
European Journal of Neuroscience, 2010AbstractFear extinction is a form of inhibitory learning that allows for the adaptive control of conditioned fear responses. Although fear extinction is an active learning process that eventually leads to the formation of a consolidated extinction memory, it is a fragile behavioural state.
Herry C. +5 more
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Reconsolidation and Fear Extinction: An Update
2023Fear memories can be updated behaviorally by delivering extinction trials during the reconsolidation window, which results in a persistent attenuation of fear memories (Monfils et al., Science 324:951-955, 2009). This safe and non-invasive paradigm, termed retrieval-extinction (or post-retrieval extinction), has also been found to be successful at ...
Marissa, Raskin, Marie-H, Monfils
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A Dopaminergic Basis for Fear Extinction
Trends in Cognitive Sciences, 2019It is a joyous relief when an event we dread fails to materialize. In fear extinction, the appetitive nature of an omitted aversive event is not a mere epiphenomenon but drives the reduction of fear responses and the formation of long-term extinction memories. Dopamine emerges as key neurobiological mediator of these related processes.
Kalisch, R. +2 more
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The Anatomy of Fear Extinction
American Journal of Psychiatry, 2006Pavlovian fear conditioning and its extinction are related laboratory procedures carried out in animals to model the mechanisms of human fear learning and its reversal. In humans, contextual (situational) fear is learned during traumatic episodes with fearful stimuli and is enhanced by genetic predisposition.
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Fear Conditioning and Extinction
2016Fear conditioning is useful in modeling the symptoms of anxiety in both humans and animal models. It is also often used as a task for examining the cognitive, behavioral, and neurobiological mechanisms underlying memory formation. After providing an overview and definitions of fear conditioning and extinction, this chapter discusses the cognitive and ...
Bronwyn M. Graham, Mohammed R. Milad
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Effects of memory age and interval of fear extinction sessions on contextual fear extinction
Neuroscience Letters, 2014Fear extinction is a major task in our understanding of the biological mechanisms of exposure therapy, one of the most used treatments for stress-related disorders. It was recently reported that an extinction of 5 consecutive days prevents spontaneous recovery of fear memory.
Shingo, Matsuda +4 more
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Neuronal circuits of fear memory and fear extinction
e-Neuroforum, 2013Abstract The paradigm“eat or be eaten” has proven to be a critical guiding element during the evolution of both humans and animals. This helps to explain the fact that the ability to detect danger or a threat has been highly conserved throughout evolution and thus exhibits a high degree of homology between species.
C.T. Wotjak, H.-C. Pape
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2019
Abstract Experimental fear conditioning and extinction represent basic forms of associative learning with considerable clinical relevance and serve as laboratory models for the development and treatment of anxiety disorders, respectively.
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Abstract Experimental fear conditioning and extinction represent basic forms of associative learning with considerable clinical relevance and serve as laboratory models for the development and treatment of anxiety disorders, respectively.
openaire +1 more source