Results 81 to 90 of about 165,251 (282)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Fear in progress? Correlates of feeling (un)safe in an urban population in Gauteng, South Africa

Cogent Social Sciences
Historically, most people have lived in fear in South Africa. Fear of the state, other social groups and crime characterised the pre-1994 South African landscape.
Pedzisai Ndagurwa, Shamsunisaa Miles-Timotheus   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Does hip bone morphology differ depending on the presence of cam lesions in borderline developmental dysplasia of the hip?

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Background: The purpose of this study was to divide patients with borderline developmental dysplasia of the hip (BDDH) into two groups according to the presence of Cam lesions, and compare radiographs related to bone morphology between them.
Yuichi Kuroda, Tomoyuki Kamenaga, Shotaro Araki, Masanori Tsubosaka, Naoki Nakano, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda   +7 more
doaj   +1 more source

Fear and stock price bubbles.

PLoS ONE, 2020
I evaluate Alan Greenspan's claim that stock price bubbles build up in periods of euphoria and tend to burst due to increasing fear. Indeed, there is evidence that e.g.
Thorsten Lehnert
doaj   +1 more source

Role of Greed and Fear Index in Investment Decision Making

SSRN Electronic Journal, 2023
Investor confidence, emotions, and psychology play a vital role in driving market upturns and downturns. Investors have gone from feeling highly optimistic with the share market regularly reaching new record highs in the period 2005-2007, to extremely pessimistic with the market falling to five-year lows in March 2009 resulting in many investors seeing
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

FEAR index in predicting treatment among patients with femoroacetabular impingement and hip dysplasia and the relationship of femoral version. [PDF]

J Hip Preserv Surg, 2022
Meyer AM, Schaver AL, Cohen BH, Glass NA, Willey MC, Westermann RW.   +5 more
europepmc   +1 more source