Results 201 to 210 of about 176,150,519 (294)

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

open access: yesAnimal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Fear of Cancer Recurrence Among Uninsured and Underrepresented Men With Prostate Cancer. [PDF]

open access: yesUrology
Shachar EK   +5 more
europepmc   +1 more source

Fecal Virome Transplantation in Human Disease and Livestock Production: Evidence, Mechanisms, and Translational Challenges

open access: yesAnimal Research and One Health, EarlyView.
Fecal virome transplantation may reshape bacterial communities and host responses while reducing viable bacterial transfer. Preclinical evidence suggests biological activity, but human efficacy remains uncertain, and translation requires product standardization, causal validation, donor–recipient matching, and rigorous biosafety assessment.
Luanyang Shi   +2 more
wiley   +1 more source

RNA‐Binding Proteins Shape Mammalian Retroelement RNA Fate: Lessons From HIV‐1, LINE‐1, and Related Reverse‐Transcribing Elements

open access: yesAnimal Research and One Health, EarlyView.
RNA‐binding proteins (RBPs) and RNA‐associated factors shape retroelement RNA fate by regulating RNA processing, translation, RNP assembly and remodeling, reverse transcription, nuclear trafficking, chromatin engagement, and RNA surveillance. These pathways balance productive retroviral replication or retrotransposon insertion with RNA decay ...
Mingrui Li, Zhangyuan Pan, Yongjuan Guan
wiley   +1 more source

Nonmelanoma Skin Cancer Risk With JAK Inhibitors Compared to Interleukin‐6 Receptor Inhibitors in Rheumatoid Arthritis: Results From a National Cohort Study

open access: yesArthritis &Rheumatology, EarlyView.
Objective Nonmelanoma skin cancer (NMSC) is one of the most common malignancies in rheumatoid arthritis (RA). This analysis assessed NMSC risk with JAK inhibitors (JAKi) compared to interleukin‐6 receptor inhibitors (IL‐6Ri). Methods This study used data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis linked to the
Zixing Tian   +8 more
wiley   +1 more source

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

open access: yesArthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic   +7 more
wiley   +1 more source

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