Results 41 to 50 of about 173,462,332 (279)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Fear and avoidance of shoulder movement according to the International Code of Functioning: cross-sectional study

BrJP
BACKGROUND AND OBJECTIVES: Shoulder pain is a limiting condition that has a major impact on daily activities and work. Knowing which specific activities involving the shoulder are associated with the occurrence of higher levels of pain may be of interest
Wellington Fernando de Paes Biondi, Marcela Camargo Tozzo, Felipe José Jandre dos Reis, Gisele Harumi Hotta, Rafael Krasic Alaiti, Anamaria Siriani de Oliveira   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Avoidance Behavioral Difference in Acquisition and Extinction of Pain-Related Fear

Frontiers in Behavioral Neuroscience, 2019
Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the ...
Yuki Nishi, Michihiro Osumi, Satoshi Nobusako, Satoshi Nobusako, Kenta Takeda, Shu Morioka, Shu Morioka   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Identifying modifiable factors that influence walking in patients undergoing surgery for neurogenic claudication: a prospective longitudinal study

Scientific Reports
Neurogenic claudication, caused by lumbar spinal stenosis, is the most common reason for spinal surgery in older adults, aiming to improve pain and walking. However, most people do not increase walking post-operatively.
Suzanne McIlroy, Lindsay Bearne, John Weinman, Sam Norton   +3 more
doaj   +1 more source

Out of control: The role of spider movement and intolerance of uncertainty in spider fear

Journal of Experimental Psychopathology, 2023
When asking spider-phobic individuals what they find most frightening about spiders, many report spiders’ unique movement characteristics. Here, we experimentally tested whether spider-specific movements are indeed a major cue in triggering spider fear ...
Markus Grill, Anke Haberkamp
doaj   +1 more source

Patellofemoral pain over time: Protocol for a prospective, longitudinal study investigating physical and non-physical features

Frontiers in Sports and Active Living, 2023
BackgroundThis is a protocol for a prospective longitudinal study that aims to investigate: (1) group-by-time changes over a minimum of 15 months follow-up in patellofemoral pain (PFP) symptoms, biomechanical, muscle function, pain processing, and ...
Ana Flavia Balotari Botta, Marina Cabral Waiteman, Matheus Henrique Maiolini Ducatti, Carmen Lúcia Gomes Garcia, Lucca André Liporoni Bego Farinelli, David Matthew Bazett-Jones, Ronaldo Valdir Briani, Fábio Mícolis de Azevedo   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source