Results 111 to 120 of about 301,580 (307)

Tokophobia: a fear of childbirth and pregnancy - an overview

International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Tokophobia is a mental disorder that affects women of all ages and varies from a mild to severe dread of delivery. Knauer first reported in the literature in 1897 that between 20% to 78% of pregnant women experience dread connected to pregnancy and delivery.
Mudit Bhardwaj, Aashutosh Sinwal, Vishv Sagar Sharma, Smrithimol Baby, Shagun Singh   +4 more
openaire   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Factors contributing to fear of childbirth among pregnant women in Hamadan (Iran) in 2016

Electronic Physician, 2017
Background: Fear of childbirth is a considerable mental, social, and physiological phenomenon among women as well as their families, which can be effective in choosing cesarean section for delivery.
Farzaneh Soltani,, Zahra Eskandari, Batoul Khodakarami, Parisa Parsa, Ghodratollah Roshanaei   +4 more
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Fear of Childbirth during Pregnancy and Birth Planning 

Abstract Background Pregnancy is a period during which a woman experiences numerous hormonal, psychological, physiological, and social changes. Those changes may lead to increased anxiety, and in some cases, the development of mental health disorders.
Patrycja Guzewicz, Matylda Sierakowska
openaire   +1 more source

Fear of childbirth during pregnancy: A study of more than 8000 pregnant women

Journal of Psychosomatic Obstetrics & Gynecology, 2002
In today's modern obstetrics, perinatal morbidity and mortality of mother and neonate have become extremely rare. Despite these advances, are pregnant women still afraid of childbearing and, if so, what--and how intense--are their fears? Are these fears influenced by previous birthing experiences and by birth preparation classes?
V, Geissbuehler, J, Eberhard
openaire   +2 more sources

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Fear of Childbirth among Pregnant Women of Various Ethnicities Referring to Comprehensive Health Service Centers in Gorgan, Iran (2023) [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Fear of childbirth is a common problem during pregnancy. Previous studies have shown that pregnancy outcomes and experiences can significantly vary across various ethnic groups.
Fahimeh Tajari, Saba Poolaie, Fatemeh Mehravar, Akram Sanagoo, Leila Jouybari   +4 more
doaj  

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source