Results 61 to 70 of about 174,572,443 (269)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Members of the United Daughters of the Confederacy, Cape Fear Chapter No. 3 wearing bonnets

, 1966
Unidentified members of the United Daughters of the Confederacy, Cape Fear Chapter No.

core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Fear of disease progression and related factors among chronic disease patients attending South Wollo zone government hospitals

Scientific Reports
Fear of disease progression is a common problem among patients with chronic disease. However, to the authors’ knowledge, it was not studied in Ethiopia. Thus, this study aimed to assess fear of disease progression and related factors among patients with ...
Sisay Gedamu Addis, Abebe Dires, Debrnesh Goshiye, Mitaw Girma, Mulusew Zeleke, Dessalegn Haile, Adane Birhanu Nigat, Abraham Tsedalu Amare   +7 more
doaj   +1 more source

The mediating effect of stigma on the relationship between fear of disease progression and social alienation in patients with haematological malignancies

Hematology
Objective: To explore the mediating effect of shame in patients with malignant haematological diseases between fear of disease progression and social alienation.Methods: Recruiting 310 patients with haematological malignancies as the research population,
Dan Shi, Run Li, PeiXin Chen, JiaQing Zhong, KuiLi Wang, Dan Wang, HuiJuan Zhu   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Officers of the Daughters of the American Revolution

Officers of the Daughters of the American Revolution, likely the Stamp Defiance Chapter, local to the Cape Fear area. Included are seated: Mrs. E.L. Robbins, Mrs. Leon R. Pierce, Mrs. Kyle Bannerman, Mrs.
Cape Fear Studio
core   +1 more source