Results 51 to 60 of about 2,391,444 (295)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Troops and Family Care Fund Feasibility Study [PDF]
, 2008 Estimates the numbers, needs, and resources of military personnel deployed in or returning from Iraq and/or Afghanistan and their families in the District of Columbia, Maryland, and Virginia.
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Feasibility Study of Logic Circuits with Spin Wave Bus [PDF]
, 2007 We present a feasibility study of logic circuits utilizing spin waves for information transmission and processing. As an alternative approach to the transistor-based architecture, logic circuits with spin wave bus do not use charge as an information ...
Bao, Mingqiang +4 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Agritech, 2020 This study aims to determine the feasibility of potatoes farming in Kutabawa Village, Karangeja District, Purbalingga Regency, and farming risks such as production, price, and income.
Yusuf Enril Fathurrohman
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Feasibility Analysis of the Development Plan of Air Putih-Selat Baru Road from Traffic Perspectives
Journal of Applied Geospatial InformationAlong with the development of the population and according to the spatial layout of the Bengkalis Regency, a road plan is needed that can facilitate movement from Bengkalis District to Bantan District.
Asni Susanti, Faisal Ananda
doaj +1 more source
Economic Feasibility Study of Photovoltaic Panels Installation by PVsyst 6.73 Simulator [PDF]
, 2018 The increasing pursuit of industry modernization presenting efficiency gains, productivity and cost reduction raises the discussion about the use of new technologies that promote, simultaneously, business sustainability and productive and economic ...
Aguiar, C. D. (Cristiane) +2 more
core