Results 31 to 40 of about 809,365 (289)

The NFDA-Nonsmooth Feasible Directions Algorithm applied to construction of Pareto Fronts of Ridge and Lasso Regressions

open access: yesTrends in Computational and Applied Mathematics
Ridge and Lasso regressions are types of linear regression, a machine learning tool for dealing with data. Based on multiobjective optimization theory, we transform Ridge and Lasso regression into bi-objective optimization problems. The Pareto fronts of
W. P. Freire
doaj   +1 more source

TWO TIME-SCALE FEASIBLE DIRECTION METHOD

open access: yesIFAC Proceedings Volumes, 2005
Abstract Stochastic constrained optimization problems with non-convex objective and convex feasible domain are considered for the case where the objective and constraint functions are available only throuth noisy observations. A general algorithm of the two time-scale stochastic approximation type is proposed for these problems.
Vladislav B. Tadić   +2 more
openaire   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Editors' Introduction

open access: yesCritical Hermeneutics, 2021
An overview of the relationship between psychoanalysis and hermeneutics. We would like to open this introduction by confessing an initial ambition that we now see with a more critical eye.
Giuseppe Martini   +1 more
doaj   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Free-Space Quantum Secure Direct Communication: Basics, Progress, and Outlook

open access: yesAdvanced Devices & Instrumentation, 2023
Quantum secure direct communication (QSDC) leverages quantum states to transmit information securely and reliably over a noisy, lossy, and wiretapped quantum channel. It has been proven to be information-theoretically secure. Recent experiments show that
Dong Pan, Xiao-Tian Song, Gui-Lu Long
doaj   +1 more source

Feasibility of Determining Diffuse Ultra-High Energy Cosmic Neutrino Flavor Ratio through ARA Neutrino Observatory

open access: yes, 2013
The flavor composition of ultra-high energy cosmic neutrinos (UHECN) carries precious information about the physical properties of their sources, the nature of neutrino oscillations and possible exotic physics involved during the propagation. Since UHECN
Chen, Pisin   +3 more
core   +1 more source

An extension of the method of feasible directions [PDF]

open access: yes, 1975
In this contribution we are going to discuss the extension of the method of feasible directions[1],[2],[3] to programming problems involving an infinite number of constraints. Problems of this type arise frequently in applications. We shall be working with arbitrary convex approximations instead of with linearizations, simply to emphasize the fact that
E. Blum, W. Oettli
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Journal Staff [PDF]

open access: yes, 1996
This thesis concerns the development of novel feasible direction type algorithms for constrained nonlinear optimization. The new algorithms are based upon enhancements of the search direction determination and the line search steps.
Mitradjieva-Daneva, Maria
core   +1 more source

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