Results 231 to 240 of about 1,514,414 (296)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Hardware-Software Integrated PCB Image Registration Method Based on Local Adaptive KNN and SIFT. [PDF]

Sensors (Basel)
Su W, Fan E, Wang J, Ling S, Fang Z.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

When high accuracy misleads in literature-derived machine learning for deep eutectic solvent recommendation. [PDF]

RSC Adv
Faraji H, Mendez-Perez JA, Rodríguez-Ramos R, Socas-Rodríguez B, Herrera Herrera AV.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A‑iMPO: A Design-Time Prediction Toolbox for Blood Brain Barrier Permeation Using an Integrated and Interpretable Multiparameter Optimization Framework. [PDF]

ACS Med Chem Lett
Phukan S, Nandy A, Ramarao M.
europepmc   +1 more source

Multimodal molecular features enable interpretable umami peptide screening and structure-activity analysis. [PDF]

Curr Res Food Sci
Li W, Yin H, Liu X, Liu Y, Zheng Z.
europepmc   +1 more source

Physics-Guided Descriptors Enable Data-Efficient Prediction of Battery Coulombic Efficiency. [PDF]

Adv Sci (Weinh)
Sun Q, Gu X, Jie Y, Yang H, Jiao S, Tang C, Sheng Y, Lu Y, Cao R, Cheng T.   +9 more
europepmc   +1 more source

Task-adaptive multimodal molecular representations for structure-sensitive property prediction. [PDF]

Chem Sci
Lin S, Zhai S, Wang S, Zhan X, Li Y, Li W, Qin L, Shi L, Tian Y, Xu K, Zhou K, Gu C, Liu H, Yao X.   +13 more
europepmc   +1 more source

Boosting the Prediction Accuracy of Glass Transition Temperature in Polyimides: A Hybrid Machine Learning Approach Integrating Morgan Fingerprints and Molecular Descriptors. [PDF]

Mol Inform
Xing P, Guo X, Wang Y, Chen Z, Shen S, He B, Li T, Peng D, Yang Z.   +8 more
europepmc   +1 more source