Results 91 to 100 of about 1,446,341 (290)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

SRMpose:Multi-Scale Feature Extraction Keypoint Detection Algorithm [PDF]

Jisuanji gongcheng
Human keypoint detection is increasingly being applied in fields such as motion behavior recognition and human-computer interaction. Taking the case of long jump, this study proposes a multi-scale feature extraction keypoint detection algorithm to ...
DAN Chonghong, WEI Honglei, HE Zhou, WU Guanfeng
doaj   +1 more source

Comments on linear feature extraction [PDF]

Linear transformation method for random data vector reduction by matrix ...
Henderson, T. L., Lainiotis, D. G.
core   +1 more source

Effective Feature Representation for Clinical Text Concept Extraction

, 2019
Crucial information about the practice of healthcare is recorded only in free-form text, which creates an enormous opportunity for high-impact NLP. However, annotated healthcare datasets tend to be small and expensive to obtain, which raises the question
Genthial, Guillaume, Godefroy, Bruno, Potts, Christopher, Tao, Yifeng   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Handwritten Arabic character recognition: which feature extraction method? [PDF]

, 2011
Recognition of Arabic handwriting characters is a difficult task due to similar appearance of some different characters. However, the selection of the method for feature extraction remains the most important step for achieving high recognition accuracy ...
Angelova, Maia, Bouridane, Ahmed, Ghassemlooy, Zabih, Lawgali, Ahmed   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cavitation identification based on feature extraction

Nuclear Engineering and Technology
Cavitation is a common phenomenon in centrifugal pumps and can result in severe damage to impellers and mechanical components, ultimately leading to significant economic losses.
Siyuan Hu, Liang Dong, Honggang Li, Weihua Shi, Runan Hua, Houlin Liu, Cui Dai   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source