Results 171 to 180 of about 1,444,731 (307)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Feature extraction tool using temporal landmarks in arterial blood pressure and photoplethysmography waveforms. [PDF]

NPJ Cardiovasc Health
Pal R, Rudas A, Williams T, Chiang JN, Barney A, Cannesson M.   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Noise-Resilient Bioacoustics Feature Extraction Methods and Their Implications on Audio Classification Performance: Systematic Review. [PDF]

JMIR Biomed Eng
Owino G, Shibwabo B.
europepmc   +1 more source

Enhanced Feature Extraction Based on Absolute Sort Delta Mean Algorithm and MFCC for Noise Robustness Speech Recognition

, 2021
A. Nosan, Suchada Sitjongsataporn, Suchada Sitjongsataporn, Mahanakorn University of Technology   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Enhanced spectro-temporal feature extraction for prosthetic control using variational mode decomposition. [PDF]

Sci Rep
Shafiq U, Waris A, Amin F, Ullah A, Ashraf H, Khan MJ, Ijaz MA, Hazzazi F, Ansari K, Gilani SO.   +9 more
europepmc   +1 more source

Automated Coronary Optical Coherence Tomography Feature Extraction with Application to Three-Dimensional Reconstruction

, 2022
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Giuseppe Di Giovanni, Jiawen Li, Peter J. Psaltis   +5 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Clinical Profile Identification of Indigenous Infants With Bronchiolitis Through Using Unsupervised Feature Extraction and Clustering. [PDF]

Pediatr Pulmonol
Niu H, McCallum GB, Chang AB, Khan K, Azam S.   +4 more
europepmc   +1 more source