Results 211 to 220 of about 2,079,458 (324)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multi-Task Cascade Forest Framework for Predicting Acute Toxicity across Species. [PDF]

Research (Wash D C)
Liu K, Li R, Wu L, Yang J, Han J, He S, Bo X, Gao J.   +7 more
europepmc   +1 more source

Heat transfer characterization of a new collector design featuring ribs, petals, and helical twisted tapes: Experimental study

Banw Omer Ahmed, Adnan Ibrahim, Hariam Luqman Azeez, Sharul Sham Dol, Ali H.A. Al‐Waeli, Mahmoud Jaber   +5 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Fusing EEG Features Extracted by Microstate Analysis and Empirical Mode Decomposition for Diagnosis of Schizophrenia. [PDF]

Sensors (Basel)
Song S, Du L, Yin J, Ling S.
europepmc   +1 more source

Larger Norm More Transferable: An Adaptive Feature Norm Approach for Unsupervised Domain Adaptation [PDF]

, 2018
Ruijia Xu, Guanbin Li, Jihan Yang, Liang Lin   +3 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Enhanced generalized normal distribution optimizer with Gaussian distribution repair method and cauchy reverse learning for features selection. [PDF]

Sci Rep
Ghetas M, Elaziz MA, Issa M.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deep transfer learning and explainable AI framework for autism spectrum disorder detection across multiple datasets. [PDF]

Front Neurol
Alsubai S.
europepmc   +1 more source