Results 71 to 80 of about 21,961 (301)

SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications

Epilepsia Open, EarlyView.
Abstract A large number of cases with Dravet syndrome (DS) has been attributed to SCN1A loss of function (LOF), whereas SCN1A gain‐of‐function (GOF) causes early infantile developmental and epileptic encephalopathy (EIDEE) and familial hemiplegic migraine 3.
Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue   +13 more
wiley   +1 more source

Influenza-Associated Encephalopathy and Febrile Convulsions

Pediatric Neurology Briefs, 2003
The transcription of cytokine genes in peripheral blood leukocytes (PBL) of 23 children (mean age 3.2 years) with influenza (mostly type A) complicated by encephalopathy (11 patients) or febrile convulsions (12 patients) was compared with systemic ...
J Gordon Millichap
doaj   +1 more source

Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series

Epilepsia Open, EarlyView.
Abstract Guanidinoacetate N‐methyltransferase deficiency is an inborn error of creatine metabolism, responsible for the absent conversion of guanidinoacetic acid into creatine, resulting in cerebral creatine deficit. It could present a variety of symptoms such as neurodevelopmental delay, epilepsy, movement disorder (ataxia, dystonia, and chorea), and ...
Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini   +5 more
wiley   +1 more source

Phenobarbital and Valproate for Febrile Convulsions

Pediatric Neurology Briefs, 1988
Data from 6 British trials of phenobarbital and 4 trials of valproate for the prophylactic treatment of febrile convulsions were polled and analyzed on an intention to treat basis at the Dept of Neurology, Royal Manchester and Booth Hall Children's ...
J Gordon Millichap
doaj   +1 more source

Prophylactic Versus Reactive (PvR) Feeding in Patients Undergoing (Chemo)radiation in Head and Neck Cancers: Results of a Phase III Randomized Controlled Trial

Head &Neck, EarlyView.
ABSTRACT Background Optimal feeding strategy (Prophylactic vs. Reactive) during Radiation Therapy (RT) for Head and Neck Cancers (HNC) remains to be established. Methods This phase III trial randomized (1:1) patients of HNC to prophylactic [nasogastric tube (NGT) placed at least 1 day before RT starting] versus reactive arm (NGT when required).
Sarbani Ghosh Laskar, Shwetabh Sinha, Meenakshi Jeeva, Meetakshi Gupta, Shreyasee Karmakar, Anuj Kumar, Samarpita Mohanty, Purabi Mahajan, Shivashankar Timmanpyati, Arun Balaji, Ashwini Budrukkar, Monali Swain, Faizalam Khan, Gouri Pantvaidya, Anuja Deshmukh, Deepa Nair, Devendra Chaukar, Prathamesh Pai, Shiva Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Pankaj Chaturvedi   +21 more
wiley   +1 more source

The Effect of Quercetin on Pro- and Anti-Inflammatory Cytokines in a Prenatally Stressed Rat Model of Febrile Seizures

Journal of Experimental Neuroscience, 2017
Febrile seizures are childhood convulsions resulting from an infection that leads to an inflammatory response and subsequent convulsions. Prenatal stress has been shown to heighten the progression and intensity of febrile seizures.
Nombuso Valencia Pearl Mkhize, Lihle Qulu, Musa Vuyisile Mabandla   +2 more
doaj   +1 more source

CSF Neopterin Levels in Febrile Convulsions

Pediatric Neurology Briefs, 1999
Neopterin, a marker for activation of the cellular immune system, and interferon-gamma were measured in the cerebrospinal fluid of 40 infants and young children (ages 0.75 to 4.6 years) admitted with fever and/or convulsions to Nippon Medical School 2nd ...
J Gordon Millichap
doaj   +1 more source

Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility. [PDF]

, 2000
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state ...
Baram, TZ, Jensen, FE
core   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Fever and Recurrent Febrile Seizures

Pediatric Neurology Briefs, 1989
The relation of the height of the fever to the recurrence rate of febrile convulsions was studied in 154 children admitted to the Paediatric Department, Ahmadi Hospital, Kuwait.
J Gordon Millichap
doaj   +1 more source