Results 101 to 110 of about 31,918 (237)

A pilot study of chemoimmunotherapy in the postconsolidation setting for high‐risk neuroblastoma (ANBL19P1): A report from the Children’s Oncology Group

Cancer, Volume 132, Issue 2, 15 January 2026.
Abstract Background Survival for patients with high‐risk neuroblastoma remains poor despite current‐era multimodality treatment that includes postconsolidation GD2‐directed immunotherapy. Given the promising responses in patients who receive dinutuximab‐based chemoimmunotherapy in the relapsed setting, the Children’s Oncology Group ANBL19P1 study ...
Ami V. Desai, Arlene Naranjo, Brian LaBarre, Lulu Chen, Kelly C. Goldsmith, Meaghan P. Granger, Lisa States, Sean G. Green, Mariel Trunzo, Wendy Fitzgerald, Steven G. DuBois, Rochelle Bagatell, Julie R. Park, Araz Marachelian   +13 more
wiley   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, Volume 158, Issue 2, Page 342-356, 15 January 2026.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

A practical approach to febrile cancer patients:  Diagnostic stewardship in Oncology units [version 2; peer review: 2 approved]

F1000Research
Introduction Cancer and cytotoxic chemotherapy used for its treatment predispose to severe and often fatal infections. Prompt diagnosis and timely antibiotic therapy are crucial, with delays in therapy initiation having high mortality.
Prashantha B., Pooja Rao, Sanyo D'souza, Anisha Maria Fernandes, Sridevi H.B., Suchitra Shenoy M   +5 more
doaj   +1 more source

Neutrophil-Lymphocyte Ratio Is Associated With Occurrence of Febrile Neutropenia in Patients Treated With 5-Fluorouracil and Cisplatin [PDF]

, 2022
Satomi Kumazawa, Tomohiro Mizuno, NAOYUKI MURAMATSU, Masakazu Hatano, Takenao Koseki, Hiroshi Matsuoka, Koichi Suda, Ichiro Uyama, Shigeki Yamada   +8 more
openalex   +1 more source

K‐means clustering‐based analysis of quantitative ultrafast DCE‐MRI for predicting breast cancer response to neoadjuvant chemotherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Purpose Achieving a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) is strongly associated with improved survival. This study investigates whether bilateral asymmetry of quantitative perfusion parameters in normal parenchyma from ultrafast dynamic contrast‐enhanced MRI (DCE‐MRI), measured using k‐means clustering ...
Zhen Ren, Xiaobing Fan, Milica Medved, Frederick M. Howard, Rita Nanda, Hiroyuki Abe, Kirti Kulkarni, Anna Biernacka, Nan Chen, Gregory S. Karczmar   +9 more
wiley   +1 more source

CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas

American Journal of Hematology, Volume 101, Issue 1, Page 110-128, January 2026.
ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
wiley   +1 more source

Reducing inappropriate antibiotic use in febrile neutropenia in hematology patients through the implementation of an antibiotic de-escalation protocol [PDF]

Jinghao Nicholas Ngiam, Victor Ling, Matthew Chung Yi Koh, Mohamed Nasar Fathima Rofina Farveen, Choong Shi Hui Clarice, Li Mei Poon, Liang Piu Koh, Nares Smitasin, Lionel Lum   +8 more
openalex   +1 more source

Heterogeneity in Treatment Effects of Reduced Versus Standard Dose of Cabazitaxel in Metastatic Castration‐Resistant Prostate Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background In the PROSELICA, a randomized controlled trial (RCT) comparing cabazitaxel 20 mg/m2 (C20) versus 25 mg/m2 (C25) in metastatic castration‐resistant prostate cancer (mCRPC), one‐variable‐at‐a‐time subgroup analysis suggested possible heterogeneity in treatment effect (HTE) of C25 versus C20 among study participants.
Wataru Fukuokaya, Keiichiro Mori, Takafumi Yanagisawa, Kagenori Ito, Fumihiko Urabe, Pawel Rajwa, Shahrokh F. Shariat, Takahiro Kimura, Akihiro Hirakawa   +8 more
wiley   +1 more source

Association of Time to Antibiotics With Outcome in Pediatric Patients Receiving Chemotherapy for Cancer With Fever in Neutropenia—An International Individual Patient Data Meta‐Analysis

Cancer Medicine, Volume 15, Issue 1, January 2026.
In an analysis of 4006 FN episodes from 2073 patients across 15 study sites in eight countries, no association was observed between shorter time to antibiotics (TTA) and reduced incidence of safety‐relevant events—including death, ICU admission, or bacteremia—regardless of whether patients presented with or without severe disease.
Amelie L. Salomon, Roland A. Ammann, Catherine Aftandilian, Konrad Bochennek, Eva Brack, Lee Dupuis, Caitlin W. Elgarten, Adam Esbenshade, Gabrielle M. Haeusler, Mia Karamatsu, Mette B. Moenster, Bob Phillips, Emily Schaeffer, Lillian Sung, Athanasios Tragiannidis, Nadja H. Vissing, Christa Koenig   +16 more
wiley   +1 more source