Results 201 to 210 of about 355,558 (363)

The risk of epilepsy after neonatal seizures

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16288 Abstract Aim To estimate the cumulative risk of epilepsy after neonatal seizures and identify subpopulations at increased risk. Method This was a nationwide register‐based cohort study including all children born in Denmark between 1997 and 2018.
Jeanette Tinggaard   +6 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón   +33 more
wiley   +1 more source

Sensitization of Non‐M3 Acute Myeloid Leukemia Blasts to All‐Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT The treatment of elderly, nonfit acute myeloid leukemia (AML)/MDS patients with relapsed/refractory (R/R) disease remains challenging. As histone demethylase LSD1 (KDM1A) is a rational therapeutic target in AML, we conducted a phase I trial (“rolling‐six design”) with the LSD1 inhibitor tranylcypromine (TCP, dose levels [DL] 20, 40, 60, 80 mg ...
Michael Kruszewski   +22 more
wiley   +1 more source

Transcriptomic and electrophysiological alterations underlying phenotypic variability in SCN1A-associated febrile seizures. [PDF]

open access: yesSci Rep
Scalise S   +18 more
europepmc   +1 more source

Developmental Febrile Seizures Modulate Hippocampal Gene Expression of Hyperpolarization-Activated Channels in an Isoform- and Cell-Specific Manner [PDF]

open access: bronze, 2002
Amy L. Brewster   +5 more
openalex   +1 more source

Community‐onset pediatric status epilepticus: Barriers to care and outcomes in a real‐world setting

open access: yesEpilepsia, Volume 66, Issue 3, Page 725-738, March 2025.
Abstract Objective Status epilepticus (SE) is a neurological emergency in childhood, often leading to neuronal damage and long‐term outcomes. The study aims to identify barriers in the pre‐hospital and in‐hospital management of community‐onset pediatric SE and to evaluate the effectiveness of pediatric scores on outcomes prediction.
Anna Fetta   +12 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera   +4 more
wiley   +1 more source

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