Results 281 to 290 of about 445,926 (335)

Dysbiosis of the gut microbiota in calcium oxalate nephrolithiasis is associated with impaired short-chain fatty acid production and systemic metabolomic disruptions. [PDF]

Microbiome
Chen X, Zhang F, Cheng L, Niu D, Hu J, Huang S, Wang F, Pang G, Huang C, Li M, Wang C, Mo Z.   +11 more
europepmc   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Novel multifunctional composite cryogel with high-performance and rapid fat-lowering efficacy via the synergy of fat digestion blockage and synthesis inhibition. [PDF]

Bioact Mater
Lu H, Lv Y, Liu S, Xu P, Shi Y, Chen Q.
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

ABCG5/ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high-cholesterol diet. [PDF]

J Lipid Res
Anspach GB, Kaur R, Chauhan I, Savage EL, Poole B, Noffsinger VP, Fu X, Wang Z, Voy C, Temel RE, Gordon SR, Helsley RN, Graf GA.   +12 more
europepmc   +1 more source

Efficacy and Mechanism of Synbiotics in Relieving Functional Constipation: Optimized by Generation Time. [PDF]

Nutrients
Wang L, Cai H, Yao Q, Chen Z, Li W, Liu C, Cui S.   +6 more
europepmc   +1 more source

Pharmacokinetics and metabolism of siamenoside I in rats. [PDF]

Toxicol Rep
Roberts A, Cuellar-Kingston N, Townley S, Ormsby T, Johnson S, van de Ligt JLG, Eapen AK.   +6 more
europepmc   +1 more source

The Pharmacokinetics, Bioavailability, and Excretion Studies of α-Cyperone in Rats by UHPLC-QQQ-MS/MS. [PDF]

Molecules
Shang Y, Zhu Y, Zhang K, Zhang Z, Geng H, Liu X, Li W, Chen L, Li C, Liu Y, Ouyang H, He J.   +11 more
europepmc   +1 more source

Strategies to reduce uric acid through gut microbiota intervention. [PDF]

Front Microbiol
Cui Y, An P, Li F, Duan F, Mei Z, Ye Q, Wang G, Zhang H, Luo Y.   +8 more
europepmc   +1 more source