Results 121 to 130 of about 6,605 (298)

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Bowel perforation surgery due to fecal impaction immediately after hernia mesh surgery (TAPP). [PDF]

J Surg Case Rep, 2022
Choi JB, Lee BC, Han JH, Noh BG, Park JK, Park YM, Jung HJ, Jo HJ.   +7 more
europepmc   +1 more source

Major Colonic Problems in Human Homotransplant Recipients [PDF]

, 1970
Brettschneider, L, Martin, A, Penn, I, Simpson, K, Starzl, TE   +4 more
core   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Rare Presentation of Stercoral Ulcer Spontaneous Perforation Without Preceding Radiographic Evidence of Colonic Inflammation and Fecal Impaction. [PDF]

Cureus, 2023
Sanekommu H, Morris A, Taj S, Imburgio S, Johal AS, Haq Z, Saleh AB, Shah P, Patel SV.   +8 more
europepmc   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

Consenso mexicano sobre el diagnóstico y tratamiento del estreñimiento en población pediátrica

Revista de Gastroenterología de México
Resumen: El estreñimiento crónico es un padecimiento común en la edad pediátrica. En los últimos años se ha observado la aplicación de nuevas medidas de diagnóstico y tratamiento, y por ello la Asociación Mexicana de Gastroenterología reunió a un panel ...
R. Figueroa-Salazar, M.A. Ruíz-Castillo, E.M. Toro-Monjaraz, L. Casas-Guzik, R. Peña-Vélez, D.V. Bacarreza-Nogales, L. Worona-Dibner, S.J. Fernández-Ortiz, L. Rodriguez, C. DiLorenzo, J.A. Chávez-Barrera, P.S. Goday, S. Díaz-Madero, J.A. Ramírez-Mayans, C. Zubiri, J. Fernández-Sobreira, K.A. Santos-Jasso   +16 more
doaj   +1 more source

A case of colonic fecal impaction caused by excessive dietary fiber intake that was endoscopically treated with intra-fecal injection of a bowel-cleansing agent. [PDF]

J Clin Transl Res, 2023
Kawabata H, Nakase K, Yamamoto T, Satake H, Yamaguchi K, Okazaki Y, Miyata M, Motoi S.   +7 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source