Results 201 to 210 of about 6,605 (298)
Clinical Pharmacology &Therapeutics, EarlyView.We evaluated whether concomitant 5‐aminosalicylic acid (5‐ASA) influences clinical remission in patients with ulcerative colitis (UC) receiving Janus kinase inhibitors (JAKi). In this retrospective, multicenter cohort study, UC patients receiving tofacitinib (n = 181), upadacitinib (n = 313), or filgotinib (n = 139) were included.
Antonio Tursi +100 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
Hot spots or hot moments? Contextualizing the spatio‐temporal scale of research on animal inputs
Ecography, EarlyView.Mammals play important roles in redistributing elements across ecosystems, concentrating biogeochemical inputs across both space and time. However, research on zoogeochemical inputs is often constrained by logistical considerations, potentially limiting our knowledge of mammals' impacts on biogeochemical patterns and processes.
Kristy M. Ferraro +3 more
wiley +1 more source
Ecography, EarlyView.Earthworms, as ‘ecosystem engineers', play a crucial role in regulating ecosystem functions and shaping community structures. Due to climate change, earthworms face severe survival pressures and extinction risks. However, whether conservation efforts targeting aboveground biodiversity can cover the long‐neglected earthworm diversity remains unknown. To
Yajie Zhou +6 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
Environmental Progress &Sustainable Energy, EarlyView.Abstract This study evaluates the potential of a new organic fertilizer derived from porcine intestinal mucosa (designated BHE), a by‐product of the heparin extraction process, as a sustainable nitrogen (N) source for agriculture. The work was conducted in two stages: (i) chemical and spectroscopic characterization of BHE compared with poultry litter ...
Aline Zanquetti +3 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza +4 more
wiley +1 more source
Modern Surgery - Chapter 27. Diseases and Injuries of the Abdomen - Stomach and Intestines [PDF]
, 1903 Da Costa, John Chalmers
core +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Anal incontinence and anal sphincter rupture during childbirth : prevelence, diagnosis and treatment [PDF]
, 2005 Pinta, Tarja
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