Results 41 to 50 of about 212,143 (187)

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Fecal incontinence and quality of life assessment through questionnaires

Journal of Coloproctology, 2017
Background: Fecal incontinence causes a big impact on patient's quality of life. Our study analyzed the main questionnaires about fecal incontinence available internationally, aiming to delineate vantages and limitations of these instruments and their ...
Beatriz Deoti Silva Rodrigues, Igor Guedes Nogueira Reis, Felipe Marcondes de Oliveira Coelho, Kelly Cristine de Lacerda Rodrigues Buzatti   +3 more
doaj   +1 more source

Management of fecal incontinence - focus on a vaginal insert for bowel control [PDF]

, 2016
Eric R Sokol Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA Abstract: Fecal incontinence, also referred to as accidental bowel leakage, is a debilitating condition that impacts quality of life in a ...
Sokol ER
core  

Exploring Symptom Domains of Postoperative Bowel Dysfunction by Integrating LARS and Wexner Scores: A Longitudinal Factor‐Analytic Study

Annals of Gastroenterological Surgery, EarlyView.
Item‐level factor analysis of the LARS and Wexner scores in 320 patients undergoing sphincter‐preserving rectal resection identified three distinct symptom domains: incontinence, urgency/clustering, and gas control. These domains had different clinical determinants: radiotherapy was associated with greater severity of both incontinence and urgency ...
Yoshiko Matsumoto, Issei Takeshita, Keiichi Shiokawa, Kurumi Sahara, Taro Munechika, Ken Nagata, Hideki Nagano, Hiroyuki Takahashi, Suguru Hasegawa   +8 more
wiley   +1 more source

Incontinence and quality of life in ulcerative colitis patients after total proctocolectomy with an ileal pouch anal anastomosis [PDF]

Iranian Journal of Colorectal Research
Objective: Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is a surgical procedure performed on patients with ulcerative colitis (UC) to avoid the need for permanent stoma.
Seyed Vahid Hosseini, Alimohamamad Bananzadeh, Mohammad Masoud Andalib, Maryam Koohestani, Zahra Sobhani, Sara Shojaei-Zarghani, Ali Reza Safarpour   +6 more
doaj   +1 more source

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

The role of rectal hyposensitivity in the development of functional hindgut disorders: clinical significance and pathophysiology [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorBackground Rectal hyposensitivity (RH) is associated with functional hindgut ...
Burgell, Rebecca Elizabeth
core   +2 more sources

The Traumatic Tube: Bleeding Rectal Ulcer Caused by Flexi-Seal Device

Case Reports in Gastrointestinal Medicine, 2017
Diarrhea and fecal incontinence are common in critically ill patients and present a challenging problem in patient management. The Flexi-Seal® Fecal Management System is a device to divert the stools away from the patient, thus improving the care to ...
Abhinav Tiwari, Himani Sharma, Khola Qamar, Yaseen Alastal, Thomas Sodeman, Ali Nawras   +5 more
doaj   +1 more source

Influence of sphincter defect on biofeedback outcomes in patients with fecal incontinence

Journal of Coloproctology, 2014
Objective: to evaluate the effect of sphincter defect (SD) on biofeedback (BF) response in patients with fecal incontinence. Methods: two hundred and forty-two patients with fecal incontinence undergoing BF as exclusive treatment were identified from a ...
Roberto L. Kaiser, Junior, Giovanna da Silva, Domingo M. Braile, Steven D. Wexner   +3 more
doaj   +1 more source