Results 81 to 90 of about 14,801 (312)

Uncertain Justice: The Ute Jurisdiction Case and Conflicting Directions in Federal Indian Law

, 2021
A J Taylor
openalex   +1 more source

Bridging the Regulatory Chasm in Investigator‐Initiated Human Subject Cannabis Research

Clinical Pharmacology &Therapeutics, EarlyView.
Heather M. Barkholtz, William Naviaux
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Differentiated policy implementation in food safety and animal welfare policymaking

European Policy Analysis, EarlyView.
Abstract Agri‐food policies are in the midst of far‐reaching transitions, including the transformation towards sustainable production and food consumption. The European Green Deal and Farm to Fork Strategy prioritize food safety and animal welfare issues, aiming to transform food systems towards more sustainability.
Giulia Bazzan, Colette S. Vogeler
wiley   +1 more source

Policy Spandrels: How Design Decisions Can Open Up Spaces for Unintended Policy Change

European Policy Analysis, EarlyView.
ABSTRACT This article introduces the concept of policy spandrels to make sense of public policies producing second‐order effects that are unintentional from the perspective of policy design and yet are fraught with consequences. By analogy with architectural spandrels—leftover spaces that can be used for unforeseen purposes—policy change can be enabled
Martino Maggetti
wiley   +1 more source

Blocked and “Unblocked” Learning: Structural Factors That Impede and Enable Evidence‐Informed Policymaking

European Policy Analysis, EarlyView.
ABSTRACT This article addresses a critical issue in evidence‐informed policymaking: the challenge of translating knowledge into policy outputs amidst the complex interplay between research and politics. It discusses the concept of “blocked learning,” where individual‐level learning fails to scale up to organizational and policy levels, thus impeding ...
Thenia Vagionaki
wiley   +1 more source

Digital Rights Activism in Multilevel Governance

European Policy Analysis, EarlyView.
ABSTRACT Multilevel governance (MLG) without a clear hierarchical structure can create power imbalances among various actors, particularly in settings with overlapping jurisdictions and policy areas. This dynamic is especially pronounced in Internet governance, which faces a complex interplay of domestic laws, state interdependence, and heightened ...
Alison Harcourt
wiley   +1 more source

SHAREHOLDERS´ CLAIMS OF A BANK IN BANKRUPTCY ON THE BASIS OF SHARE HOLDINGS

Pravo, 2007
Rehabilitation, bankruptcy and liquidation procedure are regulated by bankruptcy act. In this matter as general provision compulsory adjustment, bankruptcy and liquidation act are applied.
Miroslav Vrhovšek, Vladimir Kozar
doaj