Results 101 to 110 of about 1,764,602 (284)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

On the scaling of digital twins by aggregation

Data & Policy
We discuss the emerging technology of digital twins (DTs) and the expected demands as they scale to represent increasingly complex, interconnected systems.
Marcelo Pias, Lawrence Bull, Daniel S. Brennan, Mark Girolami, Jon Crowcroft   +4 more
doaj   +1 more source

Child Labour in the Russian Federation [PDF]

, 2002
Working paper on child labor written in 2002 for the ILO by Svetlana Stephenson, in preparation of the ILO Declaration entitled A Future Without Child Labour, under the mandate of the ILO Declaration on Fundamental Principles and Rights at ...
International Labour Office, Stephenson, Svetlana   +1 more
core   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

Strategic Perspective Codification of Iran Martial Arts Federation

Annals of Applied Sport Science, 2019
Background. The current study aimed at codifying the strategic perspective of Iranian federation of martial arts sport. Objectives. The current study aimed at investigating the negative consequences of the use of social networks at the workplace from the
Shahin Soltanpour, Seyed Mohammad Hossein Razavi, Seyed Nasrollah Sajjadi, Habib Honari   +3 more
doaj  

Home Economics in the 21st Century : A Cross Cultural Comparative Study [PDF]

, 2008
This article is reprinted with permission from the International Federation for Home Economics, August 2010Peer reviewedPublisher ...
Dewhurst, Yvonne Anne Neilson, Pendergast, Donna   +1 more
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

INFLUENCE OF THE TYPE OF STATE SYSTEM ON CONSTITUTIONAL LEGISLATION: SOME ISSUES OF THEORY AND PRACTICE (by the example of the Russian Federation and Kazakhstan Republic)

Russian Journal of Economics and Law, 2015
Objective: to study the basic laws of the constitutional law functioning of Kazakhstan Republic and the Russian Federation and its subjects in the system of law and legislation as an institutional phenomenon; to study the impact of government form on the
T. Z. Zhunuskanov
doaj  

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source