Results 181 to 190 of about 1,764,602 (284)

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

open access: yesAngewandte Chemie International Edition, EarlyView.
Used in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Sara Medina Gómez   +4 more
wiley   +1 more source

Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals

open access: yesAngewandte Chemie International Edition, EarlyView.
Endo or Exo? The first quantitative kinetic mapping of the nucleophilic reactivity of endo‐ and exo‐glycal compounds highlighted that endo‐glycals are typically 102 times less reactive than their corresponding parent cyclic enol ethers while exo‐glycals are 103 more nucleophilic. This experimental and computational structure–reactivity study highlights
Sophie Rodrigues   +7 more
wiley   +1 more source

Experimental Investigation of Microbubble Evolution in the Liquivac Multiphase Flow Pump

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This paper aims to experimentally investigate the mechanisms of microbubble characteristics evolution within an axial pump. The findings will aid in assessing the pump performance by identifying the range of bubble sizes and comparing them with the threshold size (< 300 μm). This study also provides evidence supporting the use of such pumps as
Hamad FA   +4 more
wiley   +1 more source

Descriptive, comparative, and functional anatomy of the facial musculature in cattle (Bos taurus)

open access: yesThe Anatomical Record, EarlyView.
Abstract Facial expressions can provide insight into animal emotions and pain, but no standardized system for assessing the entire facial display in cattle (Bos taurus Linnaeus) exists. The Facial Action Coding System (FACS), originally developed for humans, identifies distinct facial movements based on mimetic muscles.
Maja Söderlind   +6 more
wiley   +1 more source

HIV-1 Genetic Diversity and Drug Resistance Mutation Profiles in Donetsk, Luhansk and Zaporizhzhia Regions. [PDF]

open access: yesViruses
Antonova A   +12 more
europepmc   +1 more source

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