Results 71 to 80 of about 615,594 (260)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Economics of Federal Relations and Regional Policy [PDF]

Prostranstvennaâ Èkonomika, 2009
Considered are economic and legal foundations of federal relations, principles of federalism, peculiarities of implementation of these principles during the transition period, and methodology problems.
Valentey S. D.
doaj  

Design and Optimization of a Polar Satellite Mission to Complement the Copernicus System

IEEE Access, 2018
The space industry is currently witnessing two concurrent trends: the increased modularity and miniaturization of technologies and the deployment of constellations of distributed satellite systems.
Eduard Alarcon, Angel Alvaro Sanchez, Carles Araguz, Gilbert Barrot, Elisenda Bou-Balust, Adriano Camps, Stefania Cornara, Judith Cote, Antonio Gutierrez Pena, Estefany Lancheros, Olivia Lesne, David Llaveria, Ignasi Lluch I Ruiz, Joao Males, Antoine Mangin, Hripsime Matevosyan, Angel Monge, Janusz Narkiewicz, Stephane Ourevitch, Hyuk Park, Stephane Pierotti, Udrivolf Pica, Armen Poghosyan, Pedro Rodriguez, Joan A. Ruiz De Azua, Pierre Sicard, Mateusz Sochacki, Stefania Tonetti, Sebastian Topczewski   +28 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The Open-Multinet Upper Ontology Towards the Semantic-based Management of Federated Infrastructures

EAI Endorsed Transactions on Scalable Information Systems, 2015
The Internet remains an unfinished work. There are several approaches to enhancing it that have been experimentally validated within federated testbed environments.
Alexander Willner, Chrysa Papagianni, Mary Giatili, Paola Grosso, Mohamed Morsey, Yahya Al-Hazmi, Ilya Baldin   +6 more
doaj  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Federalism's Values and the Value of Federalism [PDF]

CESifo Economic Studies, 2008
What is it about federal governance that makes it so attractive to economists, political philosophers and legal scholars and is there any evidence that would suggest all this attention is warranted? Proponents see federalism as a means to more efficient public and private economies, as the foundation for increased political participation and democratic
openaire   +4 more sources

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source