Results 11 to 20 of about 2,522 (131)

The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade. [PDF]

J Med Virol, 2022
Abstract The humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination in patients with chronic inflammatory disease (CID) declines more rapidly with tumor necrosis factor‐α (TNF‐α) inhibition. Furthermore, the efficacy of current vaccines against Omicron variants of concern (VOC) including BA.2 is limited ...
Geisen UM, Rose R, Neumann F, Ciripoi M, Vullriede L, Reid HM, Berner DK, Bertoglio F, Hoff P, Hust M, Longardt AC, Lorentz T, Martini GR, Saggau C, Schirmer JH, Schubert M, Sümbül M, Tran F, Voß M, Zeuner R, Morrison PJ, Bacher P, Fickenscher H, Gerdes S, Peipp M, Schreiber S, Krumbholz A, Hoyer BF.   +27 more
europepmc   +2 more sources

Iron insertion into coproporphyrin III-ferrochelatase complex: Evidence for an intermediate distorted catalytic species. [PDF]

Protein Sci, 2023
Abstract Understanding the reaction mechanism of enzymes at the molecular level is generally a difficult task, since many parameters affect the turnover. Often, due to high reactivity and formation of transient species or intermediates, detailed information on enzymatic catalysis is obtained by means of model substrates.
Gabler T, Dali A, Sebastiani F, Furtmüller PG, Becucci M, Hofbauer S, Smulevich G.   +6 more
europepmc   +2 more sources

N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth. [PDF]

Br J Pharmacol, 2022
Background and Purpose N‐Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme accountable for the breakdown of N‐acylethanolamines (NAEs) and its pharmacological inhibition has beneficial effects in inflammatory conditions. The knowledge of NAAA in cancer is fragmentary with an unclarified mechanism, whereas its contribution to colorectal cancer (
Romano B, Pagano E, Iannotti FA, Piscitelli F, Brancaleone V, Lucariello G, Nanì MF, Fiorino F, Sparaco R, Vanacore G, Di Tella F, Cicia D, Lionetti R, Makriyannis A, Malamas M, De Luca M, Aprea G, D'Armiento M, Capasso R, Sbarro B, Venneri T, Di Marzo V, Borrelli F, Izzo AA.   +23 more
europepmc   +2 more sources

Freedom from disease in psoriasis: a Delphi consensus definition by patients, nurses and physicians. [PDF]

J Eur Acad Dermatol Venereol, 2022
Abstract Background Physician‐reported clinical outcome and quality of life (QoL) measures are currently used to assess outcomes and direct treatment of plaque psoriasis. However, people with psoriasis may have different criteria for judging treatment success.
van Ee I, Deprez E, Egeberg A, Augustin M, Conrad C, Corazza V, Donati L, Lambert J, Lăpădatu R, Meyer A, Paul C, Penzer-Hick R, Stephen K, van der Zon J, Bewley A.   +14 more
europepmc   +2 more sources

ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2 diabetics. [PDF]

Aging Cell, 2022
The senescence of adipose precursor cells (APC) contributes to the increased risk of Type 2 Diabetes (T2D) in both elderly subjects and young and non‐obese first‐degree relatives of T2D patients (FDR). DNA hypomethylation in the APC from FDR individuals leads to an upregulation of ZMAT3 which activates the p53/p21 pathway, causing the acquisition of ...
Spinelli R, Florese P, Parrillo L, Zatterale F, Longo M, D'Esposito V, Desiderio A, Nerstedt A, Gustafson B, Formisano P, Miele C, Raciti GA, Napoli R, Smith U, Beguinot F.   +14 more
europepmc   +2 more sources

Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination. [PDF]

Allergy
Human vaccination study discovers that booster vaccinations induce a recurring IgG antibody Fc glycosylation curve across all IgG subclasses. Proposed model: initial extrafollicular B cell activation as well as re‐activation of GC‐derived IgG+ memory B cells generate short‐lived PCs that produce highly galactosylated and sialylated short‐term IgG ...
Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt AC, Hoff P, Kalinke U, Ludwig RJ, Bartsch YC, Hoyer BF, Wuhrer M, Ehlers M.   +23 more
europepmc   +2 more sources

Biomarkers of Inflammation in Obesity-Psoriatic Patients. [PDF]

Mediators Inflamm, 2019
Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction.
Rodríguez-Cerdeira C, Cordeiro-Rodríguez M, Carnero-Gregorio M, López-Barcenas A, Martínez-Herrera E, Fabbrocini G, Sinani A, Arenas-Guzmán R, González-Cespón JL.   +8 more
europepmc   +2 more sources

Statistical analysis of probability density functions for photometric redshifts through the KiDS-ESO-DR3 galaxies [PDF]

, 2018
Despite the high accuracy of photometric redshifts (zphot) derived using Machine Learning (ML) methods, the quantification of errors through reliable and accurate Probability Density Functions (PDFs) is still an open problem.
Amaro, Valeria, Bilicki, Maciej, Brescia, Massimo, Buddelmeijer, Hugo, Cavuoti, Stefano, de Jong, Jelte T. A., Longo, Giuseppe, Napolitano, Nicola R., Radovich, Mario, Tortora, Crescenzo, Vellucci, Civita   +10 more
core   +3 more sources

Data Deluge in Astrophysics: Photometric Redshifts as a Template Use Case [PDF]

, 2018
Astronomy has entered the big data era and Machine Learning based methods have found widespread use in a large variety of astronomical applications. This is demonstrated by the recent huge increase in the number of publications making use of this new ...
A. J. Connolly, AA Collister, Abdalla, B Hoyle, C. Laigle, CA Blake, CP Ahn, D Wittman, Daniel Masters, David W. Gerdes, H Hildebrandt, I Sadeh, JTA Jong de, K Carrasco, K Carrasco, M Annunziatella, M Bolzonella, M Brescia, M Brescia, M Brescia, Masayuki Tanaka, N Benitez, O Ilbert, O Laurino, P Dubath, S Arnouts, S Cavuoti, S Cavuoti, S Cavuoti, S Cavuoti, S Cavuoti, S Cavuoti, S Cavuoti, T Gneiting   +33 more
core   +2 more sources

The Management of Thyroid Abnormalities in Chronic Heart Failure. [PDF]

, 2019
KEY POINTS Normal triiodothyronine (T3) levels are essential to preserve cardiac morphology and function. Overt and subclinical hypothyroidism are associated with an increased risk of heart failure, and levothyroxine is able to improve ...
Biondi, B
core   +1 more source