Results 31 to 40 of about 1,525,157 (341)

Redesigning Bitcoin's fee market [PDF]

open access: yes, 2017
The security of the Bitcoin system is based on having a large amount of computational power in the hands of honest miners. Such miners are incentivized to join the system and validate transactions by the payments issued by the protocol to anyone who ...
Lavi, Ron, Sattath, Or, Zohar, Aviv
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

UKRAINE: DARK PAST, UNCERTAIN FUTURE

open access: yesRevista Conjuntura Austral, 2015
The text adresses the economic evolution and recent policy of independent Ukraine. The main argument is that the Ukranian crisis has its origins long before the country's diplomacy refusal to sign an association agreement with the European Union and wave
Bruno Mariotto Jubran
doaj   +1 more source

Miniature spray-painting booth [PDF]

open access: yes, 1970
Transparent spray booth provides method for quality painting and repair of surfaces in clean room or other specialized environments. Overspray and virtually all contaminating vapor and odor can be eliminated.
Fee, K. W.
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

General paediatrics outpatient consultation fees, bulk billing rates and service use patterns in Australia

open access: yesAustralian and New Zealand Journal of Public Health, 2018
Objective: To determine: 1) the mean, median and range of fees for initial and subsequent private outpatient consultations with a general paediatrician in Australia; 2) any variation in fees and bulk billing rates between states/territories; and 3 ...
Gary L. Freed, Amy R. Allen
doaj   +1 more source

Vyhodnotenie malakofauny z náplavov Neresnice (stredné Slovensko) [PDF]

open access: yesMalacologica Bohemoslovaca, 2011
Sampling of flood debris deposits can be useful method in insufficiently surveyed areas. This sampling method also allows us to detect the presence of rare and endangered species in the study area.
Marek Čiliak, Jozef Šteffek
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Fees for Having Dogs in Cities with Poviat Rights. An analysis of an empirical research

open access: yesPrawo Budżetowe Państwa i Samorządu, 2017
The elaboration presents an analysis of issues concerning a charge in Polish cities with district rights for having a dog. The purpose of this publication is to analyse particular solutions as well as motives, which have become a determining factor in ...
Weronika Baran, Julita Tyczka
doaj   +1 more source

Malakofauna pohoria Bachureň (východné Slovensko) [PDF]

open access: yesMalacologica Bohemoslovaca, 2013
The Bachureň Mts. are the least known orographic unit of Slovakia from the malacological point of view, therefore it was important to fill this gap in the faunistic research of malacofauna in Slovakia. In order to achieve the maximum mollusc diversity of
Marek Čiliak, Jozef Šteffek
doaj   +1 more source

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