Results 131 to 140 of about 35,060 (232)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Siglec-15 promotes a feed-forward loop between TNBC cells and macrophages via the NF-κB/DcR3/CCL18/STAT3 axis. [PDF]

Transl Oncol
Wang S, Wang HQ, Zhao H, Zhao R, Zhao P, Mu Q.   +5 more
europepmc   +1 more source

Construction Immune Related Feed-Forward Loop Network Reveals Angiotensin II Receptor Blocker as Potential Neuroprotective Drug for Ischemic Stroke. [PDF]

Front Genet, 2022
Bo C, Cao Y, Li S, Zhang H, Lu X, Kong X, Zhang S, Gao H, Wang J, Wang L.   +9 more
europepmc   +1 more source

Developing Soft Interconnected Microchannel Network for 2D Skin‐Like Actuator

Advanced Science, EarlyView.
A soft interconnected network of microchannels is proposed to develop new pneumatic actuators for future bio‐inspired soft robots. Simultaneous stimulation of this network generates regional asymmetric strains in walls of microchannels whose interaction across the entire surface leads to bending curvatures in multidimensions.
John Noee, Mohammad Akbari, Josephine Perto Justsen, Ulrich Doll, Rassoul Tabassian   +4 more
wiley   +1 more source

A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours. [PDF]

EMBO Rep
Ghosh K, Kunchur A, Milán M.
europepmc   +1 more source

Construction of a TF-miRNA-gene feed-forward loop network predicts biomarkers and potential drugs for myasthenia gravis. [PDF]

Sci Rep, 2021
Bo C, Zhang H, Cao Y, Lu X, Zhang C, Li S, Kong X, Zhang X, Bai M, Tian K, Saitgareeva A, Lyaysan G, Wang J, Ning S, Wang L.   +14 more
europepmc   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

The GATA8-GRF5-XTH9 feed-forward loop regulates cell size in poplar. [PDF]

Hortic Res
Xia Y, Wu W, Ling A, Jiang S, Shu J, Wang S, Xia X, Kang X.   +7 more
europepmc   +1 more source

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. [PDF]

Oncogene, 2021
Al-Akhrass H, Conway JRW, Poulsen ASA, Paatero I, Kaivola J, Padzik A, Andersen OM, Ivaska J.   +7 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source