Results 81 to 90 of about 10,176,638 (232)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Clickers in a Flipped Lab; feedback to enhance engagement in first year Science. [PDF]
, 2017 Anecdotal evidence from lecturers engaged in teaching practical’s is that there is very little if any interaction from the students with the pre-lab reading resources as posted on Moodle or in the laboratory manuals provided at the beginning of the
O'Brien, Anne Marie
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Rocking feedback-controlled ratchets
Physical Review E, 2009 LaTeX, 8 pages, 8 figures. To appear in Phys.
Feito, M. +2 more
openaire +6 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Individual Avatar Feedback Creation for Assisted Motion Control
Current Directions in Biomedical Engineering, 2019 In Medical Training Therapy (MTT), the precise execution of the training exercises is of decisive importance for the success of the therapy. Currently, a therapist has to treat up to 15 patients simultaneously on an outpatient basis.
Lehmann Lars +2 more
doaj +1 more source
The Feedback Trombone: Controlling Feedback In Brass Instruments
, 2018 This paper presents research on control of electronic signal feedback in brass instruments through the development of a new augmented musical instrument, the Feedback Trombone. The Feedback Trombone (FBT) extends the traditional acoustic trombone interface with a speaker, microphone, and custom analog and digital hardware.
Jeff Snyder +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source