Results 71 to 80 of about 10,176,638 (232)

A Control Theory Approach to Understanding the Dynamics of Cognitive Wellbeing

Social Sciences
(1) Background and Objective: The debate on the stability and variability of subjective wellbeing (SWB) is decades old. However, despite the wealth of literature on this topic, there are relatively few studies that aim to explain the “why” and “how” of ...
Ioan Susnea, Emilia Pecheanu, Adina Cocu, Paul Iacobescu, Cornelia Tudorie, Simona Susnea   +5 more
doaj   +1 more source

A Preliminary Prototype High-Speed Feedback Control of an Artificial Cochlear Sensory Epithelium Mimicking Function of Outer Hair Cells

Micromachines, 2020
A novel feedback control technique for the local oscillation amplitude in an artificial cochlear sensory epithelium that mimics the functions of the outer hair cells in the cochlea is successfully developed and can be implemented with a control time on ...
Hiroki Yamazaki, Dan Yamanaka, Satoyuki Kawano   +2 more
doaj   +1 more source

Long-pulse H-mode operation with stored-energy monitoring for detachment feedback control with a new lower tungsten divertor in EAST

Nuclear Fusion, 2023
One of the key challenges for future fusion research is to mitigate the high steady-state heat load on the divertor target plates, and divertor detachment offers a promising solution. The Experimental Advanced Superconducting Tokamak (EAST) has developed
Y.Q. Tao, G.S. Xu, K. Wu, Q.Q. Yang, L. Wang, Q.P. Yuan, Y.F. Wang, X. Lin, L.Y. Meng, G.F. Ding, L. Yu, R. Chen, J.B. Liu, N. Yan, H. Lan, P.J. Sun, K.D. Li, J.C. Xu, Y.M. Duan, Q. Zang, Y.F. Jin, L. Zhang, S.X. Wang, K.N. Geng, R.R. Liang   +24 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Controlling Cell Migratory Patterns Under an Electric Field Regulated by a Neural Network-Based Feedback Controller

Bioengineering
Electric fields (EFs) are widely employed to promote tissue regeneration and accelerate wound healing. Despite extensive study, the cellular responses elicited by EFs are complex and not well understood.
Giovanny Marquez, Mohammad Jafari, Manasa Kesapragada, Kan Zhu, Prabhat Baniya, Yao-Hui Sun, Hao-Chieh Hsieh, Cristian O. Hernandez, Mircea Teodorescu, Marco Rolandi, Min Zhao, Marcella Gomez   +11 more
doaj   +1 more source

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Molecular Systems Biology, 2007
Robust biological signaling networks evolved, through gene duplications, from simple, relatively fragile cascades. Architectural features such as layered configuration, branching and modularity, as well as functional characteristics (e.g., feedback ...
Ido Amit, Ron Wides, Yosef Yarden
doaj   +1 more source

Feedback Control of Spin Systems [PDF]

Quantum Information Processing, 2006
The feedback stabilization problem for ensembles of coupled spin 1/2 systems is discussed from a control theoretic perspective. The noninvasive nature of the bulk measurement allows for a fully unitary and deterministic closed loop. The Lyapunov-based feedback design presented does not require spins that are selectively addressable.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source